Citation:
Mech Dev. 2002 Nov;119(1):35-44
Abstract:
The interaction between early proneural genes and lateral inhibition determines the number of primary neurons. The mechanism for regulating the size of the proneural domain, however, has not been clarified. We show here that inhibition of the function of XETOR in Xenopus, a homolog of human oncoprotein ETO/MTG8, leads to a neurogenic phenotype of expanded proneural domain without alteration in the density of primary neurons. This result suggests that XETOR is a prerequisite for regulating the size of the proneural domain. We further show that such a regulation is accomplished by establishing a negative feedback loop between XETOR and proneural genes except Xngnr-1, as well as by antagonism between XETOR and lateral inhibition.
Epub:
Not Epub
Link to Publication:
https://www.ncbi.nlm.nih.gov/pubmed/12385752
Organism or Cell Type:
Xenopus
Delivery Method:
microinjection