Citation:
Tetrahedron Lett. 2015;[Epub ahead of print] doi:10.1016/j.tetlet.2015.05.080
Abstract:
Synthesis of T-containing phosphorodiamidate morpholino oligomers (PMO) by H-phosphonate method on solid support has been reported for the first time. Initially, 5-mer then 15-mer of T-containing PMO using H-phosphonate-T monomer was synthesized on polystyrene resin bead. The phosphonamidate backbone was oxidized by iodine-dimethylamine mixture followed by the cleavage from solid support by aqueous ammonia to obtain 15-mer T-containing PMO.
Epub:
Yes
Link to Publication:
http://www.sciencedirect.com/science/article/pii/S0040403915009132