Synthesis of 5-alkynylated uracil-morpholino monomers using Sonogashira coupling

Authors:

Paul S, Nandi B, Pattanayak S, Sinha S

Citation:

Tetrahed Lett. 2012;53(32):4179-83. doi:10.1016/j.tetlet.2012.05.141

Abstract:

Sonogashira coupling of 5-iodo uracil–morpholino monomer with different terminal alkynes has been achieved for first time in good to excellent yields (67–86%). We have optimized the iodination conditions for the preparation of 5-iodo uracil–morpholino monomer under basic condition.

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Synthesis of 5-alkynylated uracil-morpholino monomers using Sonogashira coupling