Citation:
Antisense Nucleic Acid Drug Dev 1996 Winter;6(4):267-72
Abstract:
Oligomers possessing the Morpholino phosphorodiamidate backbone were evaluated for resistance to a variety of enzymes and biologic fluids. A 25-mer was incubated with nucleases, proteases, esterases, and serum, and the reaction mixtures were directly analyzed by MALDI-TOF mass spectrometry. The 25-mer was completely resistant to 13 different hydrolases and serum and plasma. The excellent resistance of Morpholino phosphorodiamidates to enzymatic attack indicates their suitability for in vivo use.
Epub:
Not Epub
Link to Publication:
https://www.liebertpub.com/doi/abs/10.1089/oli.1.1996.6.267
Organism or Cell Type:
not applicable