Citation:
Methods Mol Biol. 2017;1565:141-150. doi: 10.1007/978-1-4939-6817-6_12
Abstract:
Alternative polyadenylation is increasingly being recognized as an important layer of gene regulation. Antisense-mediated modulation of alternative polyadenylation represents an attractive strategy for the regulation of gene expression as well as potential therapeutic applications. In this chapter, we describe methods to upregulate the functional Kv11.1 isoform expression by blocking intronic polyadenylation signal sequences with antisense morpholinos.
Epub:
Not Epub
Link to Publication:
http://www.springer.com/us/book/9781493968152