Citation:
Chemistry. 2010 Jan 19. [Epub ahead of print]
Abstract:
Extension, please! A non-enzymatic DNA-template-directed synthesis approach has been developed that allows the morpholino-nucleoside extension of a PNA primer. Equilibration of the ribonucleosides with the template-primer complex, in a non-covalent fashion (see scheme), was shown to be essential for high selectivity. It is envisaged that this chemistry might be used to transcribe natures genetic material into alternative abiological polymers.