Citation:
Innovations in Pharmaceutical Technology. Sept 2005
Abstract:
Oligos which bind to complementary RNA sequences are commonly called ‘antisense’ oligos because they are typically used to bind the ‘sense’ sequence of a messenger RNA. Antisense oligos are used for identifying the function and studying the control of genes, as well as for validating prospective protein targets in drug development programmes. Such oligos also promise (but have yet to deliver) therapeutics for a broad range of currently intractable diseases. Of the several hundred oligo structural types developed over the past three decades, less than half a dozen have gained acceptance for research and biopharmaceutical development. Morpholinos are in this select group, with over a thousand scientific publications wherein Morpholinos were used.