Here's an interesting article on oligo drug impurities, written from a phosphorothioate perspective but with many ideas potentially applicable to Morpholino GMP production.
Capaldi D, Teasdale A, Henry S, Akhtar N, den Besten C, Gao-Sheridan S, Kretschmer M, Sharpe N, Andrews B, Burm B, Foy J. Impurities in Oligonucleotide Drug Substances and Drug Products. Nucleic Acid Therapeutics. December 2017, 27(6): 309-322. https://doi.org/10.1089/nat.2017.0691
http://online.liebertpub.com/doi/full/10.1089/nat.2017.0691
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