Citation:
Toxicol Appl Pharmacol. 2006 Dec 15;217(3):308-21. Epub 2006 Oct 7
Abstract:
Polycyclic aromatic hydrocarbons (PAHs) derived from fossil fuels are ubiquitous contaminants and occur in aquatic habitats as highly variable and complex mixtures of compounds containing 2 to 6 rings. For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) \"dioxin-like\" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) \"nonpolar narcosis\
Organism or Cell Type:
we show here that three tetracyclic PAHs (pyrene
Delivery Method:
in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers. As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish