ON-based drugs approved by the FDA

Here they are so far, the approved oligonucleotide drugs. Note, however, that Morpholinos are oligos but not nucleotides; Exondys 51 (eteplirsen) is the Morpholino drug.

Table 1. ON-based drugs approved by the FDA.

Trade Name; Time to Market; Company
Indication
Vitravene; 1998; Isis (Ionis)
Cytomegalovirus-induced retinitis
Macugen; 2004; Pfizer/Eyetech
Age-related macular degeneration
Kynamro; 2013; Sanofi/Isis (Ionis)
Familial hypercholesterolemia
Exondys 51; 2016; Sarepta Therapeutics
Duchenne muscular dystrophy
Spinraza; 2016; Biogen/Ionis
Spinal muscular atrophy
Defibrotide; 2016; Jazz Pharma
Severe hepatic veno-occlusive disease

From: Sun et al., Molecules 2017;22:1724. doi:10.3390/molecules22101724