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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

In vivo translatome profiling reveals early defects in ribosome biology underlying SMA pathogenesis

Authors:
Bernabò P, Tebaldi T, Groen EJN, Lane FM, Perenthaler E, Mattedi F, Newbery HJ, Zhou H, Zuccotti P, Potrich V, Muntoni F, Quattrone A, Gillingwater TH, Viero1 G
Citation:
bioRxiv. 2017. doi:10.1101/103481
Epub:
Not Epub
Abstract:
Background: Genetic alterations impacting on ubiquitously expressed proteins involved in mRNA metabolism often result in...
Link:
http://biorxiv.org/content/biorxiv/early/2017/01/26/103481.full.pdf
Delivery Method:
i.v. injection
Organism or Cell Type:
mice, SMA
Citation Extract:
Bernabò P, Tebaldi T, Groen EJN, Lane FM, Perenthaler E, Mattedi F, Newbery HJ, Zhou H, Zuccotti P, Potrich V, Muntoni F, Quattrone A, Gillingwater TH, Viero1 G. In vivo translatome profiling reveals early defects in ribosome biology underlying SMA pathogenesis. bioRxiv. 2017. doi:10.1101/103481.

Kif4 Is Essential for Mouse Oocyte Meiosis

Authors:
Camlin NJ, McLaughlin EA, Holt JE
Citation:
PLoS One. 2017 Jan 26;12(1):e0170650. doi: 10.1371/journal.pone.0170650
Epub:
Not Epub
Abstract:
Progression through the meiotic cell cycle must be strictly regulated in oocytes to generate viable embryos and offspring....
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170650
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Camlin NJ, McLaughlin EA, Holt JE. Kif4 Is Essential for Mouse Oocyte Meiosis. PLoS One. 2017 Jan 26;12(1):e0170650. doi: 10.1371/journal.pone.0170650.

The invariant cleavage pattern displayed by ascidian embryos depends on spindle positioning along the cell's longest axis in the apical plane and relies on asynchronous cell divisions

Authors:
Dumollard R, Minc N, Salez G, Ben Aicha S, Bekkouche F, Hebras C, Besnardeau L, McDougall A
Citation:
Elife. 2017 Jan 25;6. pii: e19290. doi: 10.7554/eLife.19290. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The ascidian embryo is an ideal system to investigate how cell position is determined during embryogenesis. Using 3D timelapse...
Link:
https://elifesciences.org/content/6/e19290
Delivery Method:
microinjection
Organism or Cell Type:
Phallusia mammillata (ascidian)
Citation Extract:
Dumollard R, Minc N, Salez G, Ben Aicha S, Bekkouche F, Hebras C, Besnardeau L, McDougall A. The invariant cleavage pattern displayed by ascidian embryos depends on spindle positioning along the cell's longest axis in the apical plane and relies on asynchronous cell divisions. Elife. 2017 Jan 25;6. pii: e19290. doi: 10.7554/eLife.19290. [Epub ahead of print].

Cilia Control Vascular Mural Cell Recruitment in Vertebrates

Authors:
Chen X, Gays D, Milia C, Santoro MM
Citation:
Cell Rep. 2017 Jan 24;18(4):1033-1047. doi: 10.1016/j.celrep.2016.12.044
Epub:
Not Epub
Abstract:
Vascular mural cells (vMCs) are essential components of the vertebrate vascular system, controlling blood vessel maturation and...
Link:
http://www.cell.com/cell-reports/abstract/S2211-1247(16)31749-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen X, Gays D, Milia C, Santoro MM. Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Rep. 2017 Jan 24;18(4):1033-1047. doi: 10.1016/j.celrep.2016.12.044.

Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage

Authors:
Cao X, Li C, Xiao S, Tang Y, Huang J, Zhao S, Li X, Li J, Zhang R, Yu W
Citation:
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):687-692. doi: 10.1073/pnas.1608488114
Epub:
Not Epub
Abstract:
Tyrosyl-tRNA synthetase (TyrRS) is well known for its essential aminoacylation function in protein synthesis. Recently, TyrRS...
Link:
http://www.pnas.org/content/114/4/687.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cao X, Li C, Xiao S, Tang Y, Huang J, Zhao S, Li X, Li J, Zhang R, Yu W. Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):687-692. doi: 10.1073/pnas.1608488114.

Early frameshift alleles of zebrafish tbx5a that fail to develop the heartstrings phenotype

Authors:
Chiavacci E, Kirchgeorg L, Felker A, Burger A, Mosimann C
Citation:
bioRxiv. 2017. doi:10.1101/103168
Epub:
Not Epub
Abstract:
Tbx5 is a key transcription factor for vertebrate heart and forelimb development that causes Holt-Oram syndrome when mutated in...
Link:
biorxiv.org/content/biorxiv/early/2017/01/25/103168.full.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chiavacci E, Kirchgeorg L, Felker A, Burger A, Mosimann C. Early frameshift alleles of zebrafish tbx5a that fail to develop the heartstrings phenotype. bioRxiv. 2017. doi:10.1101/103168.

Genetic Drivers of Kidney Defects in the DiGeorge Syndrome

Authors:
Lopez-Rivera E, Liu YP, Verbitsky M, Anderson BR, Capone VP, Otto EA, Yan Z, Mitrotti A, Martino J, Steers NJ, Fasel DA, Vukojevic K, Deng R, Racedo SE, Liu Q, Werth M, Westland R, Vivante A, Makar GS, Bodria M, Sampson MG, Gillies CE, Vega-Warner V, Maiorana M, Petrey DS, Honig B, Lozanovski VJ, Salomon R, Heidet L, Carpentier W, Gaillard D, Carrea A, Gesualdo L, Cusi D, Izzi C, Scolari F, van Wijk JA, Arapovic A, Saraga-Babic M, Saraga M, Kunac N, Samii A, McDonald-McGinn DM, Crowley TB, Zackai EH, Drozdz D, Miklaszewska M, Tkaczyk M, Sikora P, Szczepanska M, Mizerska-Wasiak M, <authors deleted - database limit> Tasic V, Latos-Bielenska A, Materna-Kiryluk A, Allegri L, Wong CS, Drummond IA, D'Agati V, Imamoto A, Barasch JM, Hildebrandt F, Kiryluk K, Lifton RP, Morrow BE, Jeanpierre C, Papaioannou VE, Ghiggeri GM, Gharavi AG, Katsanis N, Sanna-Cherchi S
Citation:
N Engl J Med. 2017 Jan 25. doi: 10.1056/NEJMoa1609009. [Epub ahead of print]
Epub:
Yes
Abstract:
Background The DiGeorge syndrome, the most common of the microdeletion syndromes, affects multiple organs, including the heart...
Link:
http://www.nejm.org/doi/full/10.1056/NEJMoa1609009#t=article
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lopez-Rivera E, Liu YP, Verbitsky M, Anderson BR, Capone VP, Otto EA, Yan Z, Mitrotti A, Martino J, Steers NJ, Fasel DA, Vukojevic K, Deng R, Racedo SE, Liu Q, Werth M, Westland R, Vivante A, Makar GS, Bodria M, Sampson MG, Gillies CE, Vega-Warner V, Maiorana M, Petrey DS, Honig B, Lozanovski VJ, Salomon R, Heidet L, Carpentier W, Gaillard D, Carrea A, Gesualdo L, Cusi D, Izzi C, Scolari F, van Wijk JA, Arapovic A, Saraga-Babic M, Saraga M, Kunac N, Samii A, McDonald-McGinn DM, Crowley TB, Zackai EH, Drozdz D, Miklaszewska M, Tkaczyk M, Sikora P, Szczepanska M, Mizerska-Wasiak M, <authors deleted - database limit> Tasic V, Latos-Bielenska A, Materna-Kiryluk A, Allegri L, Wong CS, Drummond IA, D'Agati V, Imamoto A, Barasch JM, Hildebrandt F, Kiryluk K, Lifton RP, Morrow BE, Jeanpierre C, Papaioannou VE, Ghiggeri GM, Gharavi AG, Katsanis N, Sanna-Cherchi S. Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. N Engl J Med. 2017 Jan 25. doi: 10.1056/NEJMoa1609009. [Epub ahead of print].

Smc1β is required for activation of SAC during mouse oocyte meiosis

Authors:
Miao Y, Zhou C, Cui Z, Dai X, Zhang M, Lu Y, Xiong B
Citation:
Cell Cycle. 2017 Jan 24:0. doi: 10.1080/15384101.2017.1282583. [Epub ahead of print]
Epub:
Yes
Abstract:
Smc1β is a meiosis-specific cohesin subunit that is essential for sister chromatid cohesion and DNA recombination. Previous...
Link:
http://www.tandfonline.com/doi/abs/10.1080/15384101.2017.1282583
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Miao Y, Zhou C, Cui Z, Dai X, Zhang M, Lu Y, Xiong B. Smc1β is required for activation of SAC during mouse oocyte meiosis. Cell Cycle. 2017 Jan 24:0. doi: 10.1080/15384101.2017.1282583. [Epub ahead of print].

Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy

Authors:
Shabanpoor F, Hammond SM, Abendroth F, Hazell G, Wood MJ, Gait MJ
Citation:
Nucleic Acid Ther. 2017 Jan 24. doi: 10.1089/nat.2016.0652. [Epub ahead of print]
Epub:
Yes
Abstract:
Splice-switching antisense oligonucleotides are emerging treatments for neuromuscular diseases, with several splice-switching...
Link:
http://online.liebertpub.com/doi/abs/10.1089/nat.2016.0652
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse
Citation Extract:
Shabanpoor F, Hammond SM, Abendroth F, Hazell G, Wood MJ, Gait MJ. Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy. Nucleic Acid Ther. 2017 Jan 24. doi: 10.1089/nat.2016.0652. [Epub ahead of print].

FGF8/17/18 functions together with FGF9/16/20 during formation of the notochord in Ciona embryos

Authors:
Yasuo H, Hudson C
Citation:
Dev Biol. 2007 Feb 1;302(1):92-103
Epub:
Not Epub
Abstract:
Fibroblast growth factor (FGF) signalling has been implicated in the generation of mesoderm and neural fates in chordate...
Link:
http://www.sciencedirect.com/science/article/pii/S0012160606011869
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Yasuo H, Hudson C. FGF8/17/18 functions together with FGF9/16/20 during formation of the notochord in Ciona embryos. Dev Biol. 2007 Feb 1;302(1):92-103.

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