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Cancer Publications Using Morpholinos (as of Summer, 2017)

This is a list of cancer research paper publications at the time of launching Onco-Tools.

Table of Contents:

Cancer Research Publications Using Morpholinos

Bone Cancer:

Bulut G, Hong SH, Chen K, Beauchamp EM, Rahim S, Kosturko GW, Glasgow E, Dakshanamurthy S, Lee HS, Daar I, Toretsky JA, Khanna C, Uren A. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-81. doi: 10.1038/onc.2011.245. Epub 2011 Jun 27. https://www.ncbi.nlm.nih.gov/pubmed/21706056

Boglev Y, Badrock AP, Trotter AJ, Du Q, Richardson EJ, Parslow AC, Markmiller SJ, Hall NE, de Jong-Curtain TA, Ng AY, Verkade H, Ober EA, Field HA, Shin D, Shin CH, Hannan KM, Hannan RD, Pearson RB, Kim S-H, Ess KC, Lieschke GJ, Stainier DYR, Heath JK. Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis. PLoS Genet. 2013;9(2):e1003279. doi:10.1371/journal.pgen.1003279. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10...

Berg MG, Wan L, Younis I, Diem MD, Soo M, Wang C, Dreyfuss G. A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis. Mol Cell Biol. 2012 Apr;32(7):1271-83. Epub 2012 Jan 17. https://www.ncbi.nlm.nih.gov/pubmed/22252314

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Brain and Nerve Cancer:

Birt-Hogg-Dubé Syndrome (Familial Cancer) Kenyon EJ, Luijten MN, Gill H, Li N, Rawlings M, Bull JC, Hadzhiev Y, van Steensel MA, Maher E, Mueller F. Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis. BMC Dev Biol. 2016 Jul 8;16(1):23. http://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-016-0119-8

Cheung HC, Baggerly KA, Tsavachidis S, Bachinski LL, Neubauer VL, Nixon TJ, Aldape KD, Cote GJ, Krahe R. Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays. BMC Genomics. 2008 May 12;9:216. https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-9-216

Ambady P, Wu YJ, Walker JM, Kersch C, Pagel MA, Woltjer RL, Fu R, Muldoon LL, Neuwelt EA. Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors. Cancer Gene Ther. 2017:[Advance publication] doi:10.1038/cgt.2017.27. http://www.nature.com/cgt/journal/vaop/ncurrent/full/cgt201727a.html

Wylie LA, Hardwick LJ, Papkovskaia TD, Thiele CJ, Philpott A. Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma. Dis Model Mech. 2015 Mar 18. pii: dmm.018630. [Epub ahead of print]. http:// dmm.biologists.org/content/8/5/429.abstract

Pei D, Luther W, Wang W, Paw BH, Stewart RA, George RE. Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models. PLoS Genet. 2013;9(6):e1003533. doi:10.1371/journal.pgen.1003533. https://www.ncbi.nlm.nih.gov/pubmed/23754957

Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1506-11. doi: 10.1073/pnas.0907763107. Epub 2010 Jan 4.. https://www.ncbi.nlm.nih.gov/pubmed/20080624

Laetsch TW, Liu X, Vu A, Sliozberg M, Vido M, Elci OU, Goldsmith KC, Hogarty MD. Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma. Cell Death Dis. 2014 Feb 20;5:e1072. doi: 10.1038/cddis.2014.40. http://www.nature.com/cddis/journal/v5/n2/full/cddis201440a.html

Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG Jr. The kinesin KIF1B{beta} acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev. 2008 Apr 1;22(7):884-93. Epub 2008 Mar 11. https://www.ncbi.nlm.nih.gov/pubmed/18334619

Cheng YC, Chiang MC, Shih HY, Ma TL, Yeh TH, Huang YC, Lin CY, Lin SJ. The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis. Dev Biol. 2014 Nov 1. pii: S0012-1606(14)00559-4. doi: 10.1016/j.ydbio.2014.10.018. [Epub ahead of print]. http://www.sciencedirect.com/science/article/pii/S0012160614005594

Huang Y-C, Shih H-Y, Lin S-J, Chiu C-C, Ma T-L, Yeh T-H, Cheng Y-C. The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation. Dev Neurobiol. 2014;[Epub ahead of print] doi:10.1002/dneu.22235. http://onlinelibrary.wiley.com/doi/10.1002/dneu.22235/abstract

Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch UK, Binder C, Pukrop T. Carcinoma cells misuse the host tissue damage response to invade the brain. Glia. 2013 Aug;61(8):1331-46. doi: 10.1002/glia.22518. Epub 2013 Jul 6. http://onlinelibrary.wiley.com/doi/10.1002/glia.22518/abstract

Ljubimova JY, Fujita M, Khazenzon NM, Ljubimov AV, Black KL. Changes in laminin isoforms associated with brain tumor invasion and angiogenesis. Front Biosci. 2006 Jan 1;11:81-8. Review. https://www.ncbi.nlm.nih.gov/pubmed/16146715

Lee BS, Fujita M, Khazenzon NM, Wawrowsky KA, Wachsmann-Hogiu S, Farkas DL, Black KL, Ljubimova JY, Holler E. Polycefin, a New Prototype of a Multifunctional Nanoconjugate Based on Poly(beta-l-malic acid) for Drug Delivery. Bioconjug Chem. 2006 Mar 15;17(2):317-326. https://www.ncbi.nlm.nih.gov/pubmed/16536461

Fujita M, Lee BS, Khazenzon NM, Penichet ML, Wawrowsky KA, Patil R, Ding H, Holler E, Black KL, Ljubimova JY. Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid). J Control Release. 2007 Oct 8;122(3):356-63. Epub 2007 Jun 5. https://www.ncbi.nlm.nih.gov/pubmed/17630012

Fujita M, Khazenzon NM, Ljubimov AV, Lee BS, Virtanen I, Holler E, Black KL, Ljubimova JY. Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis. Angiogenesis. 2006;9(4):183-91. Epub 2006 Nov 16. http://link.springer.com/article/10.1007%2Fs10456-006-9046-9

Ding H, Inoue S, Ljubimov AV, Patil R, Portilla-Arias J, Hu J, Konda B, Wawrowsky KA, Fujita M, Karabalin N, Sasaki T, Black KL, Holler E, Ljubimova JY. Inhibition of brain tumor growth by intravenous poly(beta-L-malic) acid nanobioconjugate with pH-dependent drug release. Proc Natl Acad Sci U S A. 2010 Oct 4. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/20921419

Dahmane N, Sánchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H and Altaba AR. The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 2001 128:5201-5212. https://www.ncbi.nlm.nih.gov/pubmed/11748155

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Neuroblatoma and Melanoma

Gouignard N, Maccarana M, Strate I, von Stedingk K, Malmström A, Pera EM. Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin. Dis Model Mech. 2016 Apr 21. pii: dmm.024661. [Epub ahead of print]. http://dmm.biologists.org/content/9/6/607

Boer EF, Jette CA, Stewart RA. Neural Crest Migration and Survival Are Susceptible to Morpholino-Induced Artifacts. PLoS One. 2016 Dec 22;11(12):e0167278. doi: 10.1371/journal.pone.0167278. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167278

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Breast Cancer:

Yonezawa T, Chen KH, Ghosh MK, Rivera L, Dill R, Ma L, Villa PA, Kawaminami M, Walker AM. Anti-metastatic outcome of isoform-specific prolactin receptor targeting in breast cancer. Cancer Lett. 2015 Sep 28;366(1):84-92. doi: 10.1016/j.canlet.2015.06.010. Epub 2015 Jun 18 http://www.cancerletters.info/article/S0304-3835(15)00402-4/fulltext

Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Wärri A, Hilakivi-Clarke L, Roberts DD, Clarke R. Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer. Cancer Res. 2016 Oct 1;76(19):5657-5670. http://cancerres.aacrjournals.org/content/76/19/5657

Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, AB Robertson AAB, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Smyth MJ, Cooper MA, Gambin Y, Francois M. Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife. 2017;6:e21221 doi:10.7554/eLife.21221. https://elifesciences.org/content/6/e21221

Fiskus W, Coothankandaswamy V, Chen J, Ma H, Ha K, Saenz DT, Krieger SS, Mill CP, Sun B, Huang P, Mumm JS, Melnick A, Bhalla KN. SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 to sensitize breast cancer cells to oxidant stress inducing agents. Cancer Res. 2016 Aug 8. pii: canres.0126.2016. [Epub ahead of print] doi:10.1158/0008-5472.CAN-16-0126. http://cancerres.aacrjournals.org/content/early/2016/09/07/0008-5472.CAN...

Ding H, Gangalum PR, Galstyan A, Fox I, Patil R, Hubbard P, Murali R, Ljubimova JY, Holler E. HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug. Nanomedicine. 2016 Aug 9. pii: S1549-9634(16)30103-4. doi: 10.1016/j.nano.2016.07.013. [Epub ahead of print]. http://www.nanomedjournal.com/article/S1549-9634(16)30103-4/abstract

Vad-Nielsen J, Jakobsen KR, Daugaard TF, Thomsen R, Brügmann A, Sørensen BS, Nielsen AL. Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1? down-regulation in metastatic cells. BMC Cancer. 2016;16:32. doi:10.1186/s12885-016-2059-x. http://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2059-x

Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, Charafe-Jauffret E, Chaffanet M, Castellano R, Restouin A, Marchetto S, Collette Y, Gonçalvès A, Macara I, Birnbaum D, Kodjabachian L, Johansen T, Borg J-P. Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer. Nat Comm. 2016;7:10310. doi:10.1038/ncomms10318. http://www.nature.com/ncomms/2016/160112/ncomms10318/abs/ncomms10318.html

Killedar A, Stutz MD, Sobinoff AP, Tomlinson CG, Bryan TM, Beesley J, Chenevix-Trench G, Reddel RR, Pickett HA. A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. PLoS Genet. 2015 Jun 8;11(6):e1005286. doi: 10.1371/journal.pgen.1005286. eCollection 2015 Jun. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10...

Loskutov YV, Kozyulina PY, Kozyreva VK, Ice RJ, Jones BC, Roston TJ, Smolkin MB, Ivanov AV, Wysolmerski RB, Pugacheva EN. NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. Oncogene. 2014 Sep 22. doi: 10.1038/onc.2014.297. [Epub ahead of print]. http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2014297a.html

Ljubimova JY, Portilla-Arias J, Patil R, Ding H, Inoue S, Markman JL, Rekechenetskiy A, Konda B, Gangalum PR, Chesnokova A, Ljubimov AV, Black KL, Holler E. Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment. J Drug Target. 2013 Dec;21(10):956-67. doi: 10.3109/1061186X.2013.837470. Epub 2013 Sep 16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043297/

Ding H, Helguera G, Rodríguez JA, Markman J, Luria-Pérez R, Gangalum P, Portilla-Arias J, Inoue S, Daniels-Wells TR, Black K, Holler E, Penichet ML, Ljubimova JY. Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer. J Control Release. 2013 Nov 10;171(3):322-9. doi: 10.1016/j.jconrel.2013.06.001. Epub 2013 Jun 12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971991/

Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RYS, Heinecke JL, Brueggmann E, Hines HB, Khanna C, Glynn SA, Ambs S, Wink DA. Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation. PLoS ONE. 2012;7(9): e44081. doi:10.1371/journal.pone.0044081. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044081

Maeng S, Kim GJ, Choi EJ, Yang HO, Lee DS, Sohn YC. 9-Cis-Retinoic Acid Induces Growth Inhibition in Retinoid-Sensitive Breast Cancer and Sea Urchin Embryonic Cells via Retinoid X Receptor ? and Replication Factor C3. Mol Endocrinol. 2012 Nov;26(11):1821-35. doi: 10.1210/me.2012-1104. Epub 2012 Sep 4. Https://www.ncbi.nlm.nih.gov/pubmed/22949521

Liu X, Nakamura K, Wang Y, Cheng D, Liang M, Xiao N, Chen L, Rusckowski M, Hnatowich DJ. Auger-mediated cytotoxicity of cancer cells in culture by an 125I-antisense oligomer delivered as a three-component streptavidin nanoparticle. J Biomed Nanotechnol. 2010 Apr;6(2):153-7. https://www.ncbi.nlm.nih.gov/pubmed/20738069

Hwang-Verslues WW, Chang PH, Wei PC, Yang CY, Huang CK, Kuo WH, Shew JY, Chang KJ, Lee EY, Lee WH. miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1. Oncogene. 2011 May 26;30(21):2463-74. doi: 10.1038/onc.2010.618. Epub 2011 Jan 24.. https://www.ncbi.nlm.nih.gov/pubmed/21258409

Inoue S, Patil R, Portilla-Arias J, Ding H, Konda B, Espinoza A, Mongayt D, Markman JL, Elramsisy A, Phillips HW, Black KL, Holler E, Ljubimova JY. Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer. PLoS ONE. 2012;7(2):e31070. doi:10.1371/journal.pone.0031070. https://www.ncbi.nlm.nih.gov/pubmed/22355336

Inoue S, Ding H, Portilla-Arias J, Hu J, Konda B, Fujita M, Espinoza A, Suhane S, Riley M, Gates M, Patil R, Penichet ML, Ljubimov AV, Black KL, Holler E, Ljubimova JY. Polymalic Acid-Based Nanobiopolymer Provides Efficient Systemic Breast Cancer Treatment by Inhibiting both HER2/neu Receptor Synthesis and Activity. Cancer Res. 2011 Feb 8;71(4):1454-64 [Epub ahead of print] doi:10.1158/0008-5472.CAN-10-3093. https://www.ncbi.nlm.nih.gov/pubmed/21303974

Kroeger PT Jr, Drummond BE, Miceli R, McKernan M, Gerlach GF, Marra AN, Fox A, McCampbell KK, Leshchiner I, Rodriguez-Mari A, BreMiller R, Thummel R, Davidson AJ, Postlethwait J, Goessling W, Wingert RA. The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Dev Biol. 2017 Jun 1. pii: S0012-1606(16)30468-7. doi: 10.1016/j.ydbio.2017.05.025. [Epub ahead of print]. http://www.sciencedirect.com/science/article/pii/S0012160616304687

Sandoval IT, Delacruz RGC, Miller BN, Hill S, Olson KA, Gabriel AE, Boyd K, Satterfield C, Van Remmen H, Rutter J, Jones DA. A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC). eLife. 2017;6:e22706. doi:10.7554/eLife.22706. https://elifesciences.org/content/6/e22706

Roque CG, Wong HH, Lin JQ, Holt CE. Tumor protein Tctp regulates axon development in the embryonic visual system. Development. 2016 Feb 22. pii: dev.131060. [Epub ahead of print]. http://dev.biologists.org/content/early/2016/02/22/dev.131060

Macrì S, Simula L, Pellarin I, Pegoraro S, Onorati M, Sgarra R, Manfioletti G, Vignali R. Hmga2 is required for neural crest cell specification in xenopus laevis. Dev Biol. 2016 Jan 21. pii: S0012-1606(16)30028-8. doi: 10.1016/j.ydbio.2016.01.014. [Epub ahead of print]. http://www.sciencedirect.com/science/article/pii/S0012160616300288

Cook K, Clarke P, Warri A, Clarke R. Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1. Cancer Metab. 2014;2(Suppl 1):P16. doi:10.1186/2049-3002-2-S1-P16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073063/’

Tsuruwaka Y, Konishi M, Shimada E. Loss of wwox expression in zebrafish embryos causes edema and alters Ca2+ dynamics. PeerJ. 2015;3:e727 doi:10.7717/peerj.727. https://peerj.com/articles/727/

Ljubimova JY, Ding H, Portilla-Arias J, Patil R, Gangalum PR, Chesnokova A, Inoue S, Rekechenetskiy A, Nassoura T, Black KL, Holler E. Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?. J Vis Exp. 2014;(88):e50668. doi:10.3791/50668. http://www.jove.com/video/50668/polymalic-acid-based-nano-biopolymers-fo...

Pang YF, Dong Y, Thomas P. Estrogen Signaling Characteristics of Atlantic Croaker G Protein-Coupled Receptor 30 (GPR30) and Evidence It Is Involved in Maintenance of Oocyte Meiotic Arrest. Endocrinology 2008;149(7): 3410-26. https://www.ncbi.nlm.nih.gov/pubmed/18420744

Owen LA, Uehara H, Cahoon J, Huang W, Simonis J, Ambati BK. Morpholino-Mediated Increase in Soluble Flt-1 Expression Results in Decreased Ocular and Tumor Neovascularization. PLoS ONE. 2012;7(3):e33576. doi:10.1371/journal.pone.0033576. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033576

Pache G, Schafer C, Wiesemann S, Springer E, Liebau M, Reinhardt HC, August C, Pavenstadt H, Bek MJ. Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes. Am J Physiol Renal Physiol. 2006 Sep;291(3):F654-62. Epub 2006 Apr 18. http://ajprenal.physiology.org/content/291/3/F654

Nozaki S, Sledge Jr GW, Nakshatri H. Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death. Oncogene. 2001 Apr 19;20(17):2178-85. http://www.nature.com/onc/journal/v20/n17/full/1204292a.html

McGary KL, Park TJ, Woods JO, Cha HJ, Wallingford JB, Marcotte EM. Systematic discovery of nonobvious human disease models through orthologous phenotypes. Proc Natl Acad Sci U S A. 2010 Mar 22. [Epub ahead of print]. http://www.pnas.org/content/107/14/6544.abstract

Mahadevan B, Arora V, Schild LJ, Keshava C, Cate ML, Iversen PL, Poirier MC, Weston A, Pereira C, Baird WM. Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology. Mol Carcinog. 2006 Feb;45(2):118-25.. http://onlinelibrary.wiley.com/doi/10.1002/mc.20143/full

Liu X, Wang Y, Nakamura K, Kawauchi S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. Auger Radiation-Induced, Antisense-Mediated Cytotoxicity of Tumor Cells Using a 3-Component Streptavidin-Delivery Nanoparticle with 111In. J Nucl Med. 2009 Apr;50(4):582-90. doi: 10.2967/jnumed.108.056366. Epub 2009 Mar 16. https://www.ncbi.nlm.nih.gov/pubmed/19289423

Ljubimova JY, Fujita M, Khazenzon NM, Lee BS, Wachsmann-Hogiu S, Farkas DL, Black KL, Holler E. Nanoconjugate based on polymalic acid for tumor targeting. Chem Biol Interact. 2008 Jan 30;171(2):195-203. Epub 2007 Feb 8.. https://www.ncbi.nlm.nih.gov/pubmed/17376417

Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One. 2009 Jun 26;4(6):e6025. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006025

Leung T, Chen H, Stauffer AM, Giger KE, Sinha S, Horstick EJ, Humbert JE, Hansen CA, Robishaw JD. Zebrafish G protein {gamma}2 is required for VEGF signaling during angiogenesis. Blood. 2006 Jul 1;108(1):160-6. Epub 2006 Mar 14.. https://www.ncbi.nlm.nih.gov/pubmed/16537812

Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12.. https://www.ncbi.nlm.nih.gov/pubmed/17851529

Jia D, Hasso SM, Chan J, Filingeri D, D'Amore PA, Rice L, Pampo C, Siemann DW, Zurakowski D, Rodig SJ, Moses MA. Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo. Blood. 2012 Dec 3. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/23212515

Gamba L, Cubedo N, Ghysen A, Lutfalla G, Dambly-Chaudière C. Estrogen receptor ESR1 controls cell migration by repressing chemokine receptor CXCR4 in the zebrafish posterior lateral line system. Proc Natl Acad Sci U S A. 2010 Mar 22. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/20308561

Fonar Y, Gutkovich YE, Root H, Malyarova A, Aamar E, Golubovskaya VM, Elias S, Elkouby YM, Frank D. Focal Adhesion Kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate. Mol Biol Cell. 2011 May 5. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128541/

Flores MV, Hall CJ, Davidson AJ, Singh PP, Zon LI, Crosier KE, Crosier PS. Intestinal Differentiation in Zebrafish Requires Cdx1b, a Functional Equivalent of Mammalian Cdx2. Gastroenterology. 2008 Jul 31. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/18804112

Feng Y, Santoriello C, Mione M, Hurlstone A, Martin P. Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation. PLoS Biol. 2010 Dec 14;8(12):e1000562. http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.100...

Feng Y, Renshaw S, Martin P. Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE(2). Curr Biol. 2012 Jul 10;22(13):1253-9. Epub 2012 May 31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398414/

Holloway RW, Bogachev O, Bharadwaj AG, McCluskey GD, Majdalawieh AF, Zhang L, Ro HS. Stromal adipocyte enhancer-binding protein 1 (AEBP1) promotes mammary epithelial cell hyperplasia via proinflammatory and hedgehog signaling. J Biol Chem. 2012;[Epub ahead of print] doi:10.1074/jbc.M112.404293 . http://www.jbc.org/content/early/2012/09/20/jbc.M112.404293.abstract Breast and Brain

Ding H, Patil R, Portilla-Arias J, Black KL, Ljubimova JY, Eggehard Holler E. Quantitative Analysis of PMLA Nanoconjugate Components after Backbone Cleavage. Int J Mol Sci. 2015;16(4):8607-20. doi:10.3390/ijms16048607. http://www.mdpi.com/1422-0067/16/4/8607

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Breast and Colon

Finckbeiner S, Ko PJ, Carrington B, Sood R, Gross K, Dolnick B, Sufrin J, Liu P. Transient Knockdown and Overexpression Reveal a Developmental Role for the Zebrafish enosf1b Gene. Cell & Biosci. 2011;1:32 doi:10.1186/2045-3701-1-32. https://www.ncbi.nlm.nih.gov/pubmed/21943404

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Breast, Colon, Liver

Fujii T, Tsunesumi S, Yamaguchi K, Watanabe S, Furukawa Y. Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish. PLoS One. 2011;6(8):e23491. Epub 2011 Aug 24. https://www.ncbi.nlm.nih.gov/pubmed/21887258

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Breast and Lung

Patil P, Ljubimov AV, Gangalum PR, Ding H, Portilla-Arias J, Wagner S, Inoue S, Konda B, Rekechenetskiy A, Chesnokova A, Markman JL, Ljubimov VA, Li D, Prasad RS, Black KL, Holler E, Ljubimova JY. MRI Virtual Biopsy and Treatment of Brain Metastatic Tumors with Targeted Nanobioconjugates. ACS Nano. 2015;[Epub ahead of print] doi:10.1021/acsnano.5b01872 . http://pubs.acs.org/doi/abs/10.1021/acsnano.5b01872

Miao Z, Luker KE, Summers BC, Berahovich R, Bhojani MS, Rehemtulla A, Kleer CG, Essner JJ, Nasevicius A, Luker GD, Howard MC, Schall TJ. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15735-40. Epub 2007 Sep 26. https://www.ncbi.nlm.nih.gov/pubmed/17898181

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Breast and Ovarian

Rana AA, Roper SJ, Palmer EA, Smith JC. Loss of Xenopus tropicalis EMSY causes impairment of gastrulation and upregulation of p53. N Biotechnol. 2010 Nov 4. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122151/ Joukov V, Chen J, Fox EA, Green JB, Livingston DM.. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12078-83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59770/

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Breast, Ovarian, and Prostate

Rodríguez-Marí A, Wilson C, Titus TA, Cañestro C, BreMiller RA, Yan YL, Nanda I, Johnston A, Kanki JP, Gray EM, He X, Spitsbergen J, Schindler D, Postlethwait JH. Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish. PLoS Genet. 2011;7(3): e1001357. doi:10.1371/journal.pgen.1001357. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10...

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Breast and Pancreatic

Vannier C, Mock K, Brabletz T, Driever W. Zeb1 Regulates E-cadherin and Epcam (Epithelial Cell Adhesion Molecule) Expression to Control Cell Behavior in Early Zebrafish Development. J Biol Chem. 2013 Jun 28;288(26):18643-59. doi: 10.1074/jbc.M113.467787. Epub 2013 May 10. https://www.ncbi.nlm.nih.gov/pubmed/23667256

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Cancer Therapeutics and Drug Delivery:

Summerton J. Custom Cocktail for Curing any Cancer: A Strategy for Destroying any Cancer without Harming the Patient. J Drug Discov Develop and Deliv. 2016; 3(1): 1020. http://austinpublishinggroup.com/drug-development/download.php?file=full...

Takei Y, Kadomatsu K, Yuasa K, Sato W, Muramatsu T. Morpholino antisense oligomer targeting human midkine: Its application for cancer therapy. Int J Cancer. 2005 Apr 10;114(3):490-7. https://www.ncbi.nlm.nih.gov/pubmed/15578698

Spraggon L, Cartegni L. Antisense modulation of RNA processing as a therapeutic approach in cancer therapy. Drug Discovery Today: Therapeutic Strategies. 2013;[Epub ahead of print] doi:10.1016/j.ddstr.2013.06.002. http://www.sciencedirect.com/science/article/pii/S1740677313000120

Summerton JE. Custom Cancer Therapies: Safe and Effective Treatments for Most or All Cancers. Ann N Y Acad Sci. 2003 Dec;1002:189-96. http://onlinelibrary.wiley.com/doi/10.1196/annals.1281.016/abstract

Summerton J. Intracellular inactivation of specific nucleotide sequences: a general approach to the treatment of viral diseases and virally-mediated cancers. J Theor Biol 1979 May 7;78(1):61-75. http://www.sciencedirect.com/science/article/pii/0022519379903278

Pattanayak S, Khatra H, Sahab S, Sinha S. A cationic morpholino antisense oligomer conjugate: synthesis, cellular uptake and inhibition of Gli1 in the hedgehog signalling pathway. RSC Advances. 2014;4:1951-4. doi:10.1039/C3RA45257C. http://pubs.rsc.org/En/content/articlelanding/2014/ra/c3ra45257c#!divAbs...

Nishiya N, Oku Y, Kumagai Y, Sato Y, Yamaguchi E, Sasaki A, Shoji M, Ohnishi Y, Okamoto H, Uehara Y. A Zebrafish Chemical Suppressor Screening Identifies Small Molecule Inhibitors of the Wnt/?-catenin Pathway. Chem & Biol. 2014;[Epub ahead of print] doi:10.1016/j.chembiol.2014.02.015. http://www.cell.chttp//www.cell.com/chemistry-biology/abstract/S1074-552...

Pattanayak S, Khatra H, Saha S, Sinha S. A cationic morpholino antisense oligomer conjugate: synthesis, cellular uptake and inhibition of Gli1 in the hedgehog signalling pathway. RSC Adv. 2014;4:1951-4. doi:10.1039/C3RA45257C. http://pubs.rsc.org/en/content/articlelanding/2014/ra/c3ra45257c#!divAbs...

Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML. The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitivity, is Crucial for Vascular Development. Cancer Res. 2013;[Epub ahead of print]. doi:10.1158/0008-5472.CAN-13-1981. http://cancerres.aacrjournals.org/content/early/2013/11/16/0008-5472.CAN...

Zammarchi F, de Stanchina E, Bournazou E, Supakorndej T, Martires K, Riedel E, Corben AD, Bromberg JF, Cartegni L. Antitumorigenic potential of STAT3 alternative splicing modulation. Proc Natl Acad Sci U S A. 2011 October 25; 108(43): 17779-17784. Published online 2011 October 17. doi: 10.1073/pnas.1108482108. http://www.pnas.org/content/108/43/17779.long

Zhong H, Xin S, Zhao Y, Lu J, Li S, Gong J, Yang Z, Lin S. Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish. Mol Biosyst. 2010 Aug;6(8):1463-8. Epub 2010 May 19. http://pubs.rsc.org/en/content/articlelanding/2010/mb/b919743e#!divAbstract

Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell. 2008 May 30;133(5):864-77. https://www.ncbi.nlm.nih.gov/pubmed/18510930

Shieh JJ, Liu KT, Huang SW, Chen YJ, Hsieh TY. Modification of Alternative Splicing of Mcl-1 Pre-mRNA Using Antisense Morpholino Oligonucleotides Induces Apoptosis in Basal Cell Carcinoma Cells. J Invest Dermatol. 2009 Oct;129(10):2497-506. doi: 10.1038/jid.2009.83. Epub 2009 Apr 16.. http://www.sciencedirect.com/science/article/pii/S0022202X15340902

Sazani P, Kole R. Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing. J Clin Invest. 2003 Aug;112(4):481-6. https://www.ncbi.nlm.nih.gov/pubmed/12925686?dopt=Abstract

Lee SL, Rouhi P, Jensen LD, Zhang D, Ji H, Hauptmann G, Ingham P, Cao Y. Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci U S A. 2009 Nov 3. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/19887629

Liu G, Dou S, Baker S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. A preclinical (188) Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49. Cancer Biol Ther. 2010 Oct 15;10(8):767-74. doi: 10.4161/cbt.10.8.12879. https://www.landesbioscience.com/journals/cbt/article/12879/

Liu G, Dou S, Rusckowski M, Hnatowich DJ. An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector. Mol Cancer Ther. 2008 May;7(5):1025-32. https://www.ncbi.nlm.nih.gov/pubmed/18483292

Langheinrich U, Hennen E, Stott G, Vacun G. Zebrafish as a Model Organism for the Identification and Characterization of Drugs and Genes Affecting p53 Signaling. Curr Biol. 2002 Dec 10;12(23):2023-8. https://www.ncbi.nlm.nih.gov/pubmed/12477391

Chen ZQ, Dong J, Ishimura A, Daar I, Hinnebusch A, Dean M. The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. J Biol Chem. 2006 Mar 17;281(11):7452-7. Epub 2006 Jan 18. https://www.ncbi.nlm.nih.gov/pubmed/16421098

Carmona-Fontaine C, Theveneau E, Tzekou A, Tada M, Woods M, Page KM, Parsons M, Lambris JD, Mayor R. Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration. Dev Cell. 2011 Nov 23. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/22118769

Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt M. Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development. 2007 Oct;134(19):3461-71. Epub 2007 Aug 29. https://www.ncbi.nlm.nih.gov/pubmed/17728346

Postovit LM, Margaryan NV, Seftor EA, Kirschmann DA, Lipavsky A, Wheaton WW, Abbott DE, Seftor RE, Hendrix MJ. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4329-34. Epub 2008 Mar 11. http://www.pnas.org/content/105/11/4329.abstract

Devi GR. Delivery of phosphorodiamidate morpholino antisense oligomers in cancer cells. Methods Mol Biol. 2009;542:351-61. https://www.ncbi.nlm.nih.gov/pubmed/19565912

Amatruda JF, Shepard JL, Stern HM, Zon LI. Zebrafish as a cancer model system. Cancer Cell 2002. 1(3): 229-231. https://www.ncbi.nlm.nih.gov/pubmed/12086858

Summerton JE. Invention and Early History of Morpholinos: From Pipe Dream to Practical Products. Methods Mol Biol. 2017;1565:1-15. doi: 10.1007/978-1-4939-6817-6_1. http://www.springer.com/us/book/9781493968152

Gujar R, Maurya N, Yadav V, Gupta M, Arora S, Khatri N, Sen P. c-Src Suppresses Dendritic Cell Antitumor Activity via T Cell Ig and Mucin Protein-3 Receptor. J Immunol. 2016 Sep 1;197(5):1650-62. doi: 10.4049/jimmunol.1600104. http://www.jimmunol.org/content/197/5/1650.long

del Ama LF, Jones M, Walker P, Chapman A, Braun JA, Mohr J, Hurlstone AFL. Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics. Oncotarget. 2016;[Epub ahead of print] doi:10.18632/oncotarget.9613. https://www.ncbi.nlm.nih.gov/pubmed/27248171

Summerton J. History and Properties of Morpholino Antisense Oligos. J Drug Discov Develop and Deliv. 2016; 3(1): 1019. http://austinpublishinggroup.com/drug-development/download.php?file=full...

Gong L, Gong H, Pan X, Chang C, Ou Z, Ye S, Yin L, Yang L, Tao T, Zhang Z, Liu C, Lane DP, Peng J, Chen J. p53 isoform ?113p53/?133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Res. 2015 Mar;25(3):351-69. doi: 10.1038/cr.2015.22. Epub 2015 Feb 20. http:// www.nature.com/cr/journal/v25/n3/full/cr201522a.html

Liu G. A Clearance Step will become Increasingly Crucial for Pretargeted Tumor Therapy when Tumor Accumulation is Improved. J Cancer Clin Trials. 2016;1:106. doi:10.4172/jcct.1000106. http://www.omicsonline.org/open-access/a-clearance-step-will-become-incr...

Carver K, Ming X, Juliano RL. Tumor cell-targeted delivery of nanoconjugated oligonucleotides in composite spheroids. Nucleic Acid Ther. 2014 Dec;24(6):413-9. doi: 10.1089/nat.2014.0493. http://online.liebertpub.com/doi/abs/10.1089/nat.2014.0493

Dewaele M, Tabaglio T, Willekens K, Bezzi M, Teo SX, Low DHP, Koh CM, Rambow F, Fiers M, Rogiers A, Radaelli E, Al-Haddawi M, Tan SY, Hermans E, Amant F, Yan H, Lakshmanan M, Koumar RC, Lim ST, Derheimer FA, Campbell RM, Bonday Z, Tergaonkar V, Shackleton M, Blattner C, Marine J-C, Guccione E. Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth. J Clin Invest. 2016;126(1):68-84. doi:10.1172/JCI82534. https://www.jci.org/articles/view/82534

Pattanayak S, Khatra H, Sahab S, Sinha S. A cationic morpholino antisense oligomer conjugate: synthesis, cellular uptake and inhibition of Gli1 in the hedgehog signalling pathway. RSC Adv. 2014. 4:1951-1954. doi:10.1039/C3RA45257C . http://pubs.rsc.org/en/Content/ArticleLanding/2014/RA/c3ra45257c#!divAbs...

Feng C, Nita-Lazar M, González-Montalbán N, Wang J, Mancini J, Ravindran C, Ahmed H, Vasta GR. Manipulating Galectin Expression in Zebrafish (Danio rerio). Methods Mol Biol. 2015;1207:327-41. doi: 10.1007/978-1-4939-1396-1_22. http://link.springer.com/protocol/10.1007%2F978-1-4939-1396-1_22

Soto-Pantoja DR, Terabe M, Ghosh A, Ridnour LA, DeGraff WG, Wink DA, Berzofsky JA, Roberts DD. CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy. Cancer Res. 2014 Dec 1;74(23):6771-83. doi: 10.1158/0008-5472.CAN-14-0037-T. Epub 2014 Oct 8. http://cancerres.aacrjournals.org/content/74/23/6771.abstract

Chiang PC, Hsu JL, Yeh TC, Pan SL, Guh JH. Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma. Naunyn Schmiedebergs Arch Pharmacol. 2008 Apr;377(2):167-77. Epub 2008 Jan 29. https://www.ncbi.nlm.nih.gov/pubmed/18228003

Carver K, Ming X, Juliano RL. Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions. Mol Ther Nucleic Acids. 2014;3:e153. doi:10.1038/mtna.2014.5. http://www.nature.com/mtna/journal/v3/n3/full/mtna20145a.html

Chang RM, Xiao S, Lei X, Yang H, Fang F, Yang LY. miRNA-487a Promotes Proliferation and Metastasis in Hepatocellular Carcinoma. Clin Cancer Res. 2017:[Epub ahead of print] doi:10.1158/1078-0432.CCR-16-0851. http://clincancerres.aacrjournals.org/content/23/10/2593

Chu TW, Zhang R, Yang J, Chao MP, Shami PJ, Kope?ek J. A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab. Theranostics. 2015;5(8):834-46. doi:10.7150/thno.12040. http://www.thno.org/v05p0834

Wang Y, Liu X, Nakamura K, Chen L, Rusckowski M, Hnatowich DJ. In Vivo Delivery of Antisense MORF Oligomer by MORF/Carrier Streptavidin Nanoparticles. Cancer Biother Radiopharm. 2009 Oct;24(5):573-8. doi: 10.1089/cbr.2009.0624. http://online.liebertpub.com/doi/abs/10.1089/cbr.2009.0624

Wang Y, Liu X, Chen L, Cheng D, Rusckowski M, Hnatowich DJ. Tumor delivery of antisense oligomer using trastuzumab within a streptavidin nanoparticle. Eur J Nucl Med Mol Imaging. 2009 Dec;36(12):1977-86. doi: 10.1007/s00259-009-1201-2. http://link.springer.com/article/10.1007%2Fs00259-009-1201-2

Shchelkunova A, Ermolinsky B, Boyle M, Mendez I, Lehker M, Martirosyan KS, Kazansky AV. Tuning of Alternative Splicing - Switch From Proto-Oncogene to Tumor Suppressor. Int J Biol Sci. 2013;9(1):45-54. doi:10.7150/ijbs.5194. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535533/

Ming X, Carver K, Wu L. Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides. Biomaterials. 2013 Oct;34(32):7939-49. doi: 10.1016/j.biomaterials.2013.06.066. Epub 2013 Jul 19. https://www.ncbi.nlm.nih.gov/pubmed/23876758

Liu X, Wang Y, Hnatowich DJ. A nanoparticle for tumor targeted delivery of oligomers. Methods Mol Biol. 2011;764:91-105. doi: 10.1007/978-1-61779-188-8_6. http://link.springer.com/protocol/10.1007%2F978-1-61779-188-8_6

Liu X, Wang Y, Nakamura K, Kubo A, Hnatowich DJ. Cell studies of a three-component antisense MORF/tat/Herceptin nanoparticle designed for improved tumor delivery. Cancer Gene Ther. 2008 Feb;15(2):126-32. Epub 2007 Dec 14. https://www.ncbi.nlm.nih.gov/pubmed/18084241

Liu Y, Cheng D, Liu X, Liu G, Dou S, Xiao N, Chen L, Rusckowski M, Hnatowich DJ. Comparing the intracellular fate of components within a noncovalent streptavidin nanoparticle with covalent conjugation. Nucl Med Biol. 2012 Jan;39(1):101-7. doi: 10.1016/j.nucmedbio.2011.06.006. Epub 2011 Sep 29. http://www.nucmedbio.com/article/S0969-8051%2811%2900155-7/abstract

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Cancer Treatment Side Effects: Soto-Pantoja DR, Ridnour LA, Wink DA, Roberts DD. Blockade of CD47 increases survival of mice exposed to lethal total body irradiation. Sci Reports. 2013;3:1038. doi:10.1038/srep01038. http://www.nature.com/articles/srep01038

Sorrells S, Carbonneau S, Harrington E, Chen AT, Hast B, Milash B, Pyati U, Major MB, Zhou Y, Zon LI, Stewart RA, Look AT, Jette C. Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53. PLoS Genet. 2012;(8):e1002922. doi:10.1371/journal.pgen.1002922. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10...

Speirs CK, Jernigan KK, Kim SH, Cha YI, Lin F, Sepich DS, DuBois RN, Lee E, Solnica-Krezel L. Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development. 2010 Apr;137(8):1327-37. https://www.ncbi.nlm.nih.gov/pubmed/20332150

Soto-Pantoja DR, Stein EV, Rogers NM, Sharifi-Sanjani M, Isenberg JS, Roberts DD. Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47. Expert Opin Therap Targets. 2012;[Epub ahead of print] doi:10.1517/14728222.2013.733699. https://www.ncbi.nlm.nih.gov/pubmed/23101472

Soto-Pantoja DR, Isenberg JS, Roberts DD. Therapeutic Targeting of CD47 to Modulate Tissue Responses to Ischemia and Radiation. J Genet Syndr Gene Ther. J Genet Syndr Gene Ther. 2011 October; 2(2): 1000105. https://www.ncbi.nlm.nih.gov/pubmed/22685691

Zhong H, Wang D, Wang N, Rios Y, Huang H, Li S, Wu X, Lin S. Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity. Cell Res. 2011 Mar 22. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/21423276

Eichner R, Heider M, Fernández-Sáiz V, van Bebber F, Garz AK, Lemeer S, Rudelius M, Targosz BS, Jacobs L, Knorn AM, Slawska J, Platzbecker U, Germing U, Langer C, Knop S, Einsele H, Peschel C, Haass C, Keller U, Schmid B, Götze KS, Kuster B, Bassermann F. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Nat Med. 2016 Jun 13. doi: 10.1038/nm.4128. [Epub ahead of print]. http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4128.html

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Colon Cancer:

Stagg BC, Uehara H, Lambert N, Rai R, Gupta I, Radmall B, Bates T, Ambati BK. Morpholino-Mediated Isoform Modulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Reduces Colon Cancer Xenograft Growth. Cancers. 2014;6(4):2330-42. doi:10.3390/cancers6042330. http://www.mdpi.com/2072-6694/6/4/2330

Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ. Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J Clin Invest. 2014 Apr 1. pii: 71103. doi: 10.1172/JCI71103. [Epub ahead of print]. http://www.jci.org/articles/view/71103

Wu B, Piloto S, Zeng W, Hoverter NP, Schilling TF, Waterman ML. Ring Finger Protein 14 is a new regulator of TCF/?-catenin-mediated transcription and colon cancer cell survival. EMBO Rep. 2013;14(4):347-55. doi:10.1038/embor.2013.19. Epub 2013 Mar 1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615654/

Subauste MC, Sansom OJ, Porecha N, Raich N, Du L, Maher JF. Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells. Mol Carcinog. 2010 Feb;49(2):105-13. https://www.ncbi.nlm.nih.gov/pubmed/19908242

Dai W, Bai Y, Hebda L, Zhong X, Liu J, Kao J, Duan C. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ. 2014 Apr;21(4):568-81. doi: 10.1038/cdd.2013.177. Epub 2013 Dec 13. http://www.nature.com/cdd/journal/v21/n4/full/cdd2013177a.html

Mulvaney JF, Amemiya Y, Freeman SD, Ladher RK, Dabdoub A. Molecular cloning and functional characterization of chicken Atonal homologue 1: a comparison with human Atoh1. Biol Cell. 2014 Nov 21. doi: 10.1111/boc.201400078. [Epub ahead of print]. http://onlinelibrary.wiley.com/doi/10.1111/boc.201400078/abstract

Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, Stoetzel C, Patil SB, Levy S, Ghosh AK, Murga-Zamalloa CA, van Reeuwijk J, Letteboer SJ, Sang L, Giles RH, Liu Q, Coene KL, Estrada-Cuzcano A, Collin RW, McLaughlin HM, Held S, Kasanuki JM, Ramaswami G, Conte J, Lopez I, Washburn J, Macdonald J, Hu J, Yamashita Y, Maher ER, Guay-Woodford LM, Neumann HP, Obermüller N, Koenekoop RK, Bergmann C, Bei X, Lewis RA, Katsanis N, Lopes V, Williams DS, Lyons RH, Dang CV, Brito DA, Dias MB, Zhang X, Cavalcoli JD, Nürnberg G, Nürnberg P, Pierce EA, Jackson PK, Antignac C, Saunier S, Roepman R, Dollfus H, Khanna H, Hildebrandt F. . Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet. 2010 Oct;42(10):840-50. Epub 2010 Sep 12. http://pubmedcentralcanada.ca/pmcc/articles/PMC2947620/

Mawdsley DJ, Cooper HM, Hogan BM, Cody SH, Lieschke GJ, Heath JK. The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish. Dev Biol. 2004 May 1;269(1):302-15. http://www.sciencedirect.com/science/article/pii/S0012160604000946

Eisinger AL, Nadauld LD, Shelton DN, Prescott SM, Stafforini DM, Jones DA. Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. J Biol Chem. 2007 Oct 5;282(40):29394-400. Epub 2007 Aug 2. https://www.ncbi.nlm.nih.gov/pubmed/17673467

Eisinger AL, Nadauld LD, Shelton DN, Peterson PW, Phelps RA, Chidester S, Stafforini DM, Prescott SM, Jones DA. The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. J Biol Chem. 2006 Jul 21;281(29):20474-82. Epub 2006 May 14. https://www.ncbi.nlm.nih.gov/pubmed/16699180

Shelton DN, Sandoval IT, Eisinger A, Chidester S, Ratnayake A, Ireland CM, Jones DA. Up-regulation of CYP26A1 in Adenomatous Polyposis Coli-Deficient Vertebrates via a WNT-Dependent Mechanism: Implications for Intestinal Cell Differentiation and Colon Tumor Development. Cancer Res. 2006 Aug 1;66(15):7571-7. https://www.ncbi.nlm.nih.gov/pubmed/16885356

Phelps RA, Chidester S, Dehghanizadeh S, Phelps J, Sandoval IT, Rai K, Broadbent T, Sarkar S, Burt RW, Jones DA. A two-step model for colon adenoma initiation and progression caused by APC loss. Cell. 2009 May 15;137(4):623-34. https://www.ncbi.nlm.nih.gov/pubmed/19450512

Nadauld LD, Sandoval IT, Chidester S, Yost HJ, Jones DA. Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. J Biol Chem. 2004 Dec 3;279(49):51581-9. Epub 2004 Sep 8. https://www.ncbi.nlm.nih.gov/pubmed/15358764

Kino T, Chrousos GP. Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. J Biol Chem. 2003 Jan 31;278(5):3023-9.. http://www.uniprot.org/citations/12477726

Colon, Lung, and Pancreatic

Gu Y, Shea J, Slattum G, Firpo MA, Alexander M, Mulvihill SJ, Golubovskaya VM, Rosenblatt J. Defective apical extrusion signaling contributes to aggressive tumor hallmarks. Elife. 2015 Jan 26;4:e04069. doi: 10.7554/eLife.04069. http://elifesciences.org/content/4/e04069

Colorectal Cancer (DCC):

Müller M, Persson AB, Krueger K, Kirschner KM, Scholz H. The Wilms tumor protein WT1 stimulates transcription of the gene encoding insulin-like growth factor binding protein 5 (IGFBP5). Gene. 2017 Mar 30. pii: S0378-1119(17)30217-2. doi: 10.1016/j.gene.2017.03.037. [Epub ahead of print]. http://www.sciencedirect.com/science/article/pii/S0378111917302172

Konopacki FA, Wong HH-W, Dwivedy A, Bellon A, Blower MD, Holt CE. ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis. Open Biol. 2016;6:150218. doi:10.1098/rsob.150218. http://rsob.royalsocietypublishing.org/content/6/4/150218

James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT . Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal. 2009 May 26;2(72):ra25. doi: 10.1126/scisignal.2000230. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790753/

Kastenhuber E, Kern U, Bonkowsky JL, Chien CB, Driever W, Schweitzer J. Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons. J Neurosci. 2009 Jul 15;29(28):8914-26. doi: 10.1523/JNEUROSCI.0568-09.2009. http://www.jneurosci.org/content/29/28/8914.long

Schmitt M, Metzger M, Gradl D, Davidson G, Orian-Rousseau V. CD44 functions in Wnt signaling by regulating LRP6 localization and activation. Cell Death Differ. 2014 Oct 10. doi: 10.1038/cdd.2014.156. [Epub ahead of print]. http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd2014156a.html

Young T, Poobalan Y, Tan EK, Tao S, Ong S, Wehner P, Schwenty-Lara J, Lim CY, Sadasivam A, Lovatt M, Wang ST, Ali Y, Borchers A, Sampath K, Dunn NR. The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development. 2014;141:3505-16; doi:10.1242/dev.114033. http://dev.biologists.org/content/141/18/3505.abstract

Zhang C, Gao J, Zhang H, Sun L, Peng G. Robo2-Slit and Dcc-Netrin1 Coordinate Neuron Axonal Pathfinding within the Embryonic Axon Tracts. J Neurosci. 2012;32(36):12589-602. doi:10.1523/JNEUROSCI.6518-11.2012. http://www.jneurosci.org/content/32/36/12589

Xie Y, Ding YQ, Hong Y, Feng Z, Navarre S, Xi CX, Zhu XJ, Wang CL, Ackerman SL, Kozlowski D, Mei L, Xiong WC. Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. Nat Cell Biol. 2005 Nov;7(11):1124-32.. http://www.nature.com/ncb/journal/v7/n11/full/ncb1321.html

Suli A, Mortimer N, Shepherd I, Chien CB. Netrin/DCC signaling controls contralateral dendrites of octavolateralis efferent neurons. J Neurosci. 2006 Dec 20;26(51):13328-37. http://www.jneurosci.org/content/26/51/13328

Mahmoudi T, Boj SF, Hatzis P, Li VSW, Taouatas N, Vries RGJ, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJR, Clevers H. The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/?-Catenin Coactivators Essential for Intestinal Homeostasis. PLoS Biol. 2010;8(11): e1000539. doi:10.1371/journal.pbio.1000539. http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.100...

Laguinge LM, Samara RN, Wang W, El-Deiry WS, Corner G, Augenlicht L, Mishra L, Jessup JM. DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. Cancer Res. 2008 Feb 1;68(3):909-17. https://www.ncbi.nlm.nih.gov/pubmed/18245494

Lakhina V, Marcaccio CL, Shao X, Lush ME, Jain RA, Fujimoto E, Bonkowsky JL, Granato M, Raper JA. Netrin/DCC Signaling Guides Olfactory Sensory Axons to Their Correct Location in the Olfactory Bulb. J Neurosci. 2012;32(13):4440-4456. doi:10.1523/JNEUROSCI.4442-11.2012 https://www.ncbi.nlm.nih.gov/pubmed/22457493

James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT. Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal. 2009 May 26;2(72):ra25. https://www.ncbi.nlm.nih.gov/pubmed/19471023

Imajo M, Miyatake K, Iimura A, Miyamoto A, Nishida E. A molecular mechanism that links Hippo signalling to the inhibition of Wnt/?-catenin signalling. EMBO J. 2012 Jan 10;31(5):1109-22. doi: 10.1038/emboj.2011.487. https://www.ncbi.nlm.nih.gov/pubmed/22234184

Gao J, Zhang C, Yang B, Sun L, Zhang C, Westerfield M, Peng G. Dcc Regulates Asymmetric Outgrowth of Forebrain Neurons in Zebrafish. PLoS ONE. 2012;7(5): e36516. doi:10.1371/journal.pone.0036516. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036516

Angonin D, Van Raay TJ. Nkd1 Functions as a Passive Antagonist of Wnt Signaling. PLoS ONE. 2013;8(8):e74666. doi:10.1371/journal.pone.0074666. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074666

Satow R, Shitashige M, Jigami T, Honda K, Ono M, Hirohashi S, Yamada T. Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation. J Biol Chem. 2010 Jun 21. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/20566648

Roy HK, Iversen P, Hart J, Liu Y, Koetsier JL, Kim Y, Kunte DP, Madugula M, Backman V, Wali RK. Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: Modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther. 2004 Sep;3(9):1159-65. http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.133.1492&rep=re...

Colorectal and Gastric

Wei S, Shang H, Cao Y, Wang Q. The coiled-coil domain containing protein Ccdc136b antagonizes maternal Wnt/?-catenin activity during zebrafish dorsoventral axial patterning. J Genet Genomics. 2016 May 11. pii: S1673-8527(16)30051-0. doi: 10.1016/j.jgg.2016.05.003. [Epub ahead of print]. http://www.sciencedirect.com/science/article/pii/S1673852716300510

Colorectal and Kidney

Kirikoshi H, Katoh M. Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. Int J Oncol. 2002 Mar;20(3):571-6. https://www.ncbi.nlm.nih.gov/pubmed/11836570

Epithelial Cancer:

Shepard JL, Amatruda JF, Finkelstein D, Ziai J, Finley KR, Stern HM, Chiang K, Hersey C, Barut B, Freeman JL, Lee C, Glickman JN, Kutok JL, Aster JC, Zon LI. A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes Dev. 2007 Jan 1;21(1):55-9. https://www.ncbi.nlm.nih.gov/pubmed/17210788

Lahat G, Zhu QS, Huang KL, Wang S, Bolshakov S, Liu J, Torres K, Langley RR, Lazar AJ, Hung MC, Lev D. Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One. 2010 Apr 16;5(4):e10105. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855704/

Esophageal Squamous Cancer:

Kim K, Nakagawa H, Fei P, Rustgi AK, El-Deiry WS. Targeting Bcl-x(L) in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9. Cell Death Differ. 2004 May;11(5):583-7. No abstract available. http://www.nature.com/cdd/journal/v11/n5/full/4401388a.html

Leukemia:

Daakour S, Hajingabo LJ, Kerselidou D, Aurelie Devresse A, Kettmann R, Simonis N, Dequiedt F, Twizere J-C. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. BMC Cancer. 2016;16:335 doi:10.1186/s12885-016-2374-2. http://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2374-2

Li RA, Traver D, Matthes T, Bertrand JY. Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish. Blood. 2016 Dec 29;128(26):3052-3060. doi: 10.1182/blood-2016-09-742502. http://www.bloodjournal.org/content/128/26/3052

Li FQ, Person RE, Takemaru KI, Williams K, Meade-White K, Ozsahin AH, Gungor T, Moon RT, Horwitz M. Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor {alpha} Regulation of ELA2. J Biol Chem. 2004 Jan 23; 279(4): 2873-2884. Epub 2003 Oct 31. https://www.ncbi.nlm.nih.gov/pubmed/14594802

Witzel M, Petersheim D, Fan Y, Bahrami E, Racek T, Rohlfs M, Pucha?ka J, Mertes C, Gagneur J, Ziegenhain C, Enard W, Stray-Pedersen A, Arkwright PD, Abboud MR, Pazhakh V, Lieschke GJ, Krawitz PM, Dahlhoff M, Schneider MR, Wolf E, Horny HP, Schmidt H, Schäffer AA, Klein C. Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes. Nat Genet. 2017 Apr 3. doi: 10.1038/ng.3833. [Epub ahead of print]. http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3833.html

Dayyani F, Wang J, Yeh JR, Ahn EY, Tobey E, Zhang DE, Bernstein ID, Peterson RT, Sweetser DA. Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperate with AML1-ETO to affect myeloid cell proliferation and survival. Blood. 2008 Apr 15;111(8):4338-47. Epub 2008 Feb 7.. https://www.ncbi.nlm.nih.gov/pubmed/18258796

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Liver Cancer:

Han W, Lee H, Han J-K. Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling. Sci Rep. 2017;7:42590 doi:10.1038/srep42590. http://www.nature.com/articles/srep42590

Fujisawa K, Terai S, Matsumoto T, Takami T, Yamamoto N, Nishina H, Furutani-Seiki M, Sakaida I. Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging. PLoS ONE. 2015;10(6): e0129950. doi:10.1371/journal.pone.0129950. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129950

Lee TKW, Cheung VCH, Lu P, Lau EYT, Ma S, Tang KH, Tong M, Lo J, Ng IOL. Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma. Hepatology. 2014;[Epub ahead of print] doi:10.1002/hep.27070. http://onlinelibrary.wiley.com/doi/10.1002/hep.27070/abstract

Yeh TC, Chiang PC, Li TK, Hsu JL, Lin CJ, Wang SW, Peng CY, Guh JH. Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult. Biochem Pharmacol. 2007 Mar 15;73(6):782-92. Epub 2006 Dec 3. http://www.sciencedirect.com/science/article/pii/S0006295206008021

Monga SP, Monga HK, Tan X, Mule K, Pediaditakis P, Michalopoulos GK. beta-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification. Gastroenterology. 2003 Jan;124(1):202-216. http://www.gastrojournal.org/article/S0016-5085(03)50032-4/abstract

Zhao Y, Huang X, Ding TW, Gong Z. Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish. Sci Rep. 2016 Aug 23;6:31952. doi: 10.1038/srep31952. http://www.nature.com/articles/srep31952

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Lung Cancer:

Park SA, Platt J, Lee JW, López-Giráldez F, Herbst RS, Koo JS. E2F8 as a Novel Therapeutic Target for Lung Cancer. J Natl Cancer Inst. 2015 Jun 18;107(9). pii: djv151. doi: 10.1093/jnci/djv151. Print 2015 Sep. http://jnci.oxfordjournals.org/content/107/9/djv151.abstract

Washio K, Aoe M, Toyooka S, Mushiake H, Tsukuda K, Shimizu N.. The effect of epidermal growth factor receptor antisense morpholino oligomer on non-small cell lung cancer cell line.. Oncol Rep. 2003 Nov-Dec;10(6):1967-71.. https://www.ncbi.nlm.nih.gov/pubmed/19188161

Sekhon HS, London CA, Sekhon M, Iversen PL, Devi GR. c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model. Lung Cancer. 2008 Jun;60(3):347-54. Epub 2007 Dec 21. https://www.ncbi.nlm.nih.gov/pubmed/18096271

Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E, Basbaum C.. Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha converting enzyme and amphiregulin.. J Biol Chem 2003 Apr 23; [epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/12711607

Knapp DC, Mata JE, Reddy MT, Devi GR, Iversen PL. Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model. Anticancer Drugs. 2003 Jan;14(1):39-47. https://www.ncbi.nlm.nih.gov/pubmed/12544257

Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C. TACE/ADAM-17 Phosphorylation by PKC-Epsilon Mediates Premalignant Changes in Tobacco Smoke-Exposed Lung Cells. PLoS ONE. 2011;6(3):e17489. doi:10.1371/journal.pone.0017489. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017489

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Lung and Cervical

Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L. Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal. 2011 Jan 25;4(157):ra4. doi: 10.1126/scisignal.2001225. https://www.ncbi.nlm.nih.gov/pubmed/21266715

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Lymphoma:

Zhang L, Fang Y, Yang J, Kope?ek J. Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells. J Control Release. 2016 Dec 23. pii: S0168-3659(16)31273-1. doi: 10.1016/j.jconrel.2016.12.025. [Epub ahead of print]. http://www.sciencedirect.com/science/article/pii/S0168365916312731

Yang F, Xiong J, Jia X-E, Gu Z-H, Shi J-Y, Zhao Y, Li J-M, Chen S-J, Zhao W-L. GSTT1 Deletion Is Related to Polycyclic Aromatic Hydrocarbons-Induced DNA Damage and Lymphoma Progression. PLoS ONE. 2014;9(2):e89302. doi:10.1371/journal.pone.0089302. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0089302

Chu T-W, Yang J, Zhang R, Sima M, Kopecek J. Cell Surface Self-Assembly of Hybrid Nanoconjugates via Oligonucleotide Hybridization Induces Apoptosis. ACS Nano. 2013;[epub ahead of print] doi:10.1021/nn4053827. http://pubs.acs.org/doi/abs/10.1021/nn4053827

Yao S, Cheng M, Zhang Q, Wasik M, Kelsh R, Winkler C. Anaplastic Lymphoma Kinase Is Required for Neurogenesis in the Developing Central Nervous System of Zebrafish. PLoS ONE. 2013;8(5):e63757. doi:10.1371/journal.pone.0063757. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063757

Nan Y, Patel D, Zhang Y. Inhibition of KSHV-associated lymphoma engraftment in SCID mouse by morpholino oligomers. Infect Agent Cancer. 2010; 5(Suppl 1): A40. Epub 2010 Oct 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002700/

Arnaud E, Ferri KF, Thibaut J, Haftek-Terreau Z, Aouacheria A, Le Guellec D, Lorca T, Gillet G. The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and -independent mechanisms. Cell Death Differ. 2006 Jul;13(7):1128-37. Epub 2005 Nov 11. The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and -independent mechanisms

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Miscellaneous Cancer Related Research:

Ming X, Wu L, Carver K, Yuan A, Min Y. Dendritic Nanoconjugates for Intracellular Delivery of Neutral Oligonucleotides. Nanoscale. 2015;[Epub ahead of print] doi:10.1039/C5NR01665G. http://pubs.rsc.org/en/content/articlelanding/2015/nr/c5nr01665g#!divAbs...

Belgacem YH, Borodinsky LN. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4140-5. doi: 10.1073/pnas.1419690112. Epub 2015 Mar 17. http://www.pnas.org/content/112/13/4140.long

Tena TC, Philipp M. Assessing Smoothened-mediated Hedgehog signaling in zebrafish. Methods Cell Biol. 2016;132:147-64. doi: 10.1016/bs.mcb.2015.10.001. Epub 2015 Dec 24. http://www.sciencedirect.com/science/article/pii/S0091679X15001946

Metikala S, Neuhaus H, Hollemann T. Suppression of vascular network formation by chronic hypoxia and prolyl-hydroxylase 2 (phd2) deficiency during vertebrate development. Angiogenesis. 2015 Dec 17. [Epub ahead of print] doi:10.?1007/?s10456-015-9492-3. http://link.springer.com/article/10.1007%2Fs10456-015-9492-3

Costa G, Harrington KI, Lovegrove HE, Page DJ, Chakravartula S, Bentley K, Herbert SP. Asymmetric division coordinates collective cell migration in angiogenesis. Nat Cell Biol. 2016 Dec;18(12):1292-1301. doi: 10.1038/ncb3443. http://www.nature.com/ncb/journal/v18/n12/full/ncb3443.html

Matrone G, Mullins JJ, Tucker CS, Denvir MA. Effects of Cyclin Dependent Kinase 9 inhibition on zebrafish larvae. Cell Cycle. 2016 Oct 7: [Epub ahead of print] doi:10.1080/15384101.2016.1231283 http://www.tandfonline.com/doi/full/10.1080/15384101.2016.1231283

Bronchain O, Jdey W, Caraty L, Ciapa. Role of Mad2 expression during the early development of the sea urchin. Int J Dev Biol. B2017;61(6-7):451-457. doi: 10.1387/ijdb.170053bc. http://www.ijdb.ehu.es/web/paper/170053bc/role-of-mad2-expression-during...

He X, Zhang W, Yan C, Nie F, Li C, Liu X, Fei C, Li D, Song X, Jia Y, Zeng R, Wu D, Pan W, Hao X, Li L. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity. Cell Disc. 2017;3:17003. doi:10.1038/celldisc.2017.3. http://www.nature.com/articles/celldisc20173

Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Changh CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W.. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci USA. 2016;[Epub ahead of print] doi:10.1073/pnas.1600204113. http://www.pnas.org/content/early/2016/08/31/1600204113.abstract

Simon AJ, Lev A, Zhang Y, Weiss B, Rylova A, Eyal E, Kol N, Bare O, Cesarkas K, Soudack M, Greenberg-Kushnir N, Rhodes M, Wiest DL, Schiby G, Barshack I, Katz S, Pras E, Poran H, Reznik-Wolf H, Ribakovsky E, Simon C, Hazou W, Sidi Y, Lahad A, Katzir H, Sagie S, Aqeilan HA, Glousker G, Amariglio N, Tzfati Y, Selig S, Rechavi G, Somech R. Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. J Exp Med. 2016;[Epub ahead of print] doi:10.1084/jem.20151618. http://jem.rupress.org/content/early/2016/07/13/jem.20151618.abstract

Zinc and Transporters Involved in Cell Migration During Development and Cancer Taylor KM, Muraina I, Brethour D, Schmitt-Ulms G, Nimmanon T, Ziliotto S, Kille P, Hogstrand C. Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration. Biochem J. 2016 Jun 7. pii: BCJ20160388. [Epub ahead of print]. http://www.biochemj.org/content/early/2016/06/07/BCJ20160388.long

Holloway MP, DeNardo BD, Phornphutkul C, Nguyen K, Davis C, Jackson C, Richendrfer H, Creton R, Altura RA. An asymptomatic mutation complicating severe chemotherapy-induced peripheral neuropathy (CIPN): a case for personalised medicine and a zebrafish model of CIPN. npj Genomic Med. 2016;1:16016. doi:10.1038/npjgenmed.2016.16. http://www.nature.com/articles/npjgenmed201616

Lai YR, Lu YF, Lien HW, Huang CJ, Hwang SL. Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos. Biochem J. 2016 May 24. pii: BCJ20160392. [Epub ahead of print]. http://www.biochemj.org/content/early/2016/05/24/BCJ20160392

Salewsky B, Hildebrand G, Rothe S, Parplys AC, Radszewski J, Kieslich M, Wessendorf P, Krenzlin H, Borgmann K, Nussenzweig A, Sperling K, Digweed M. Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application. Mol Ther. 2016 Feb;24(1):117-24. doi: 10.1038/mt.2015.144. Epub 2015 Aug 12.. http://www.nature.com/mt/journal/vaop/ncurrent/full/mt2015144a.html

Antunes AT, Goos YJ, Pereboom TC, Hermkens D, Wlodarski MW, Da Costa L, MacInnes AW. Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway. PLoS Genet. 2015;11(7):e1005326. doi:10.1371/journal.pgen.1005326. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10...

Xiang Y, Stine ZE, Xia J, Lu Y, O’Connor RS, Altman BJ, Hsieh AL, Gouw AM, Thomas AG, Gao P, Sun L, Song L, Yan B, Slusher BS, Zhuo J, Ooi LL, Lee CGL, Mancuso A, McCallion AS, Le A, Milone MC, Rayport S, Felsher DW, Dang CV. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest. 2015;[Epub ahead of print] doi:10.1172/JCI75836. http://www.jci.org/articles/view/75836

Schwamb B, Pick R, Fernández SB, Völp K, Heering J, Dötsch V, Bösser S, Jung J, Beinoraviciute-Kellner R, Wesely J, Zörnig I, Hammerschmidt M, Nowak M, Penzel R, Zatloukal K, Joos S, Rieker RJ, Agaimy A, Söder S, Reid-Lombardo K, Kendrick ML, Bardsley MR, Hayashi Y, Asuzu DT, Syed SA, Ordog T, Zörnig M. FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. Int J Cancer. 2015 Feb 25. doi: 10.1002/ijc.29498. [Epub ahead of print]. http://onlinelibrary.wiley.com/doi/10.1002/ijc.29498/abstract

Huang J, Zhang H, Wang X, Dobbs KB, Yao J, Qin G, Whitworth K, Walters EM, Prather RS, Zhao J. Impairment of Preimplantation Porcine Embryo Development by Histone Demethylase KDM5B Knockdown Through Disturbance of Bivalent H3K4me3-H3K27me3 Modifications. Biol Reprod. 2015 Jan 21. pii: biolreprod.114.122762. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/25609834

Tsai M, Lu Y, Liu Y, Lien H, Huang C, Wu J, Hwang SL. Modulation of p53 and met expression by krüppel-like factor 8 regulates zebrafish cerebellar development. Dev Neurobiol. 2014 Dec 19. doi: 10.1002/dneu.22258. [Epub ahead of print]. http://onlinelibrary.wiley.com/doi/10.1002/dneu.22258/abstract

Markham NO, Doll CA, Dohn MR, Miller RK, Yu H, Coffey RJ, McCrea PD, Gamse JT, Reynolds AB. DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia. Mol Biol Cell. 2014 Sep 1;25(17):2592-603. doi: 10.1091/mbc.E13-08-0492. Epub 2014 Jul 9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148249/

Chang GH, Lay AJ, Ting KK, Zhao Y, Coleman PR, Powter EE, Formaz-Preston A, Jolly CJ, Bower NI, Hogan BM, Rinkwitz S, Becker TS, Vadas MA, Gamble JR. ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. Small GTPases. 2014 Nov 25:0. [Epub ahead of print]. http://www.tandfonline.com/doi/abs/10.4161/21541248.2014.975002#.VHy3QMk...

Sugathan A, Biagioli M, Golzio C, Erdin S, Blumenthal I, Manavalan P, Ragavendran A, Brand H, Lucente D, Miles J, Sheridan SD, Stortchevoi A, Kellis M, Haggarty SJ, Katsanis N, Gusella JF, Talkowski ME. CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors. PNAS. 2014;111(42):E4468-E4477. published ahead of print October 7, 2014, doi:10.1073/pnas.1405266111. http://www.pnas.org/content/111/42/E4468.abstract

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Liu G, Dou S, Liang M, Chen X, Rusckowski R, Hnatowich DJ. The ratio of maximum percent tumor accumulations of the pretargeting agent and the radiolabeled effector is independent of tumor size. Eur J Cancer. 2009 Nov;45(17):3098-103. doi: 10.1016/j.ejca.2009.09.007. Epub 2009 Oct 5. http://www.ejcancer.com/article/S0959-8049%2809%2900679-0/abstract

Liu G, Mang'era K, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. Tumor Pretargeting in Mice Using (99m)Tc-Labeled Morpholino, a DNA Analog. J Nucl Med. 2002 Mar;43(3):384-391. https://www.ncbi.nlm.nih.gov/pubmed/11884499

Liu G, Dou S, Pretorius PH, Liu X, Chen L, Rusckowski M, Hnatowich DJ. Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector. Q J Nucl Med Mol Imaging. 2010 Jun;54(3):333-40. Epub 2009 Dec 15. http://www.minervamedica.it/en/journals/nuclear-med-molecular-imaging/ar...

Liu D, Wang WD, Melville DB, Cha YI, Yin Z, Issaeva N, Knapik EW, Yarbrough WG. Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly. Dev Dyn. 2011 Apr 26. doi: 10.1002/dvdy.22644. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/21523853

Li L, Wen L, Gong Y, Mei G, Liu J, Chen Y, Peng T. Xenopus as a Model System for the Study of GOLPH2/GP73 Function: Xenopus golph2 Is Required for Pronephros Development. PLoS ONE. 2012;7(6):e38939. doi:10.1371/journal.pone.0038939. https://www.ncbi.nlm.nih.gov/pubmed/22719994

Leacock SW, Basse AN, Chandler GL, Kirk AM, Rakheja D, Amatruda JF. A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis. Dis Model Mech. 2012 Jan;5(1):95-106. Epub 2011 Oct 6. https://www.ncbi.nlm.nih.gov/pubmed/21979944

Lalwani MK, Sharma M, Singh AR, Chauhan RK, Patowary A, Singh N, Scaria V, Sivasubbu S. Reverse Genetics Screen in Zebrafish Identifies a Role of miR-142a-3p in Vascular Development and Integrity. PLoS ONE. 2012;7(12):e52588. doi:10.1371/journal.pone.0052588. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052588

Jin Z, Wallace L, Harper SQ, Yang J. PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and -independent apoptosis during development. J Biol Chem. 2010 Nov 5;285(45):34493-502. doi: 10.1074/jbc.M110.169581. Epub 2010 Aug 31. http://www.ajceog.us/files/ajceog0007334.pdf

Janssens S, Van Den Broek O, Davenport IR, Akkers RC, Liu F, Veenstra GJ, Hoppler S, Vleminckx K, Destrée O. The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation. Int J Dev Biol. 2013;57(1):49-54. doi: 10.1387/ijdb.120191kv. https://www.ncbi.nlm.nih.gov/pubmed/23585352

Izaguirre DI, Zhu W, Hai T, Cheung HC, Krahe R, Cote GJ. PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis. Mol Carcinog. 2012 Nov;51(11):895-906. doi: 10.1002/mc.20859. Epub 2011 Oct 4.. https://www.ncbi.nlm.nih.gov/pubmed/21976412

Huang XD, McGann JC, Liu BY, Hannoush RN, Lill JR, Pham V, Newton K, Kakunda M, Liu J, Yu C, Hymowitz SG, Hongo J-A, Wynshaw-Boris A, Polakis P, Harland RM, Dixit VM. Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling. Science. 2013;339(6126);1441-1445. doi:10.1126/science.1232253. https://www.ncbi.nlm.nih.gov/pubmed/23371553

Hollenbach M, Stoll SJ, Jörgens K, Seufferlein T, Kroll J. Different Regulation of Physiological and Tumor Angiogenesis in Zebrafish by Protein Kinase D1 (PKD1). PLoS ONE. 2013;8(7):e68033. doi:10.1371/journal.pone.0068033. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068033

He J, Wang Y, Dou S, Liu X, Zhang S, Liu G, Hnatowich D. Affinity Enhancement Pretargeting: synthesis and testing of a 99mTc-labeled bivalent MORF. Mol Pharm. 2010 Aug 2;7(4):1118-24. doi: 10.1021/mp9002909. http://pubs.acs.org/doi/abs/10.1021/mp9002909

He J, Liu G, Gupta S, Zhang Y, Rusckowski M, Hnatowich DJ. Amplification targeting: a modified pretargeting approach with potential for signal amplification-proof of a concept. J Nucl Med. 2004 Jun;45(6):1087-95. https://www.ncbi.nlm.nih.gov/pubmed/15181145

He J, Liu G, Dou S, Gupta S, Rusckowski M, Hnatowich D. An Improved Method for Covalently Conjugating Morpholino Oligomers to Antitumor Antibodies. Bioconjug Chem. 2007 May-Jun;18(3):983-8. Epub 2007 Mar 27.. https://www.ncbi.nlm.nih.gov/pubmed/17385902

Goto HG, Nishizawa Y, Katayama H, Murashima T, Yamasaki M, Tanigaki Y, Kimura S, Fushiki S, Nishizawa Y. Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene. Oncol Rep. 2007 Jan;17(1):225-32. https://www.ncbi.nlm.nih.gov/pubmed/17143502

Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell. 2005 Apr 8;121(1):87-99. https://www.ncbi.nlm.nih.gov/pubmed/15820681

Croushore JA, Blasiole B, Riddle RC, Thisse C, Thisse B, Canfield VA, Robertson GP, Cheng KC, Levenson R. Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Dev Dyn. 2005 Dec;234(4):911-21.. https://www.ncbi.nlm.nih.gov/pubmed/16193492

Cheng D, Wang Y, Liu X, Pretorius PH, Liang M, Rusckowski M, Hnatowich DJ. Comparison of (18)F PET and (99m)Tc SPECT Imaging in Phantoms and in Tumored Mice. Bioconjug Chem. 2010 Aug 3. [Epub ahead of print]. http://pubs.acs.org/doi/abs/10.1021/bc1001467

Cha HJ, Byrom M, Mead PE, Ellington AD, Wallingford JB, Marcotte EM. Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol. 2012 Aug;10(8):e1001379. Epub 2012 Aug 21. http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.100...

Castellanos EC, Rosas I, Solanes A, Bielsa I, Lazaro C, Carrato C, Hostalot C, Prades P, Roca-Ribas F, Blanco I, Serra E. In vitro antisense therapeutics for a deep intronic mutation causing Neurofibromatosis type 2. Eur J Hum Genet. 2012;[Epub ahead of print] doi:10.1038/ejhg.2012.261. https://www.ncbi.nlm.nih.gov/pubmed/23188051

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Cancer Invasion

Moore R, Theveneau E, Pozzi S, Alexandre P, Richardson J, Merks A, Parsons M, Kashef J, Linker C, Mayor R. Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion. Development. 2013 Oct 30. [Epub ahead of print]. http://dev.biologists.org/content/140/23/4763

Weiser DC, Row RH, Kimelman D. Rho-regulated Myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation. Development. 2009 Jun 10. [Epub ahead of print]. http://dev.biologists.org/content/136/14/2375

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Epithelial-Mesenchymal Transition

Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J. 2011 Sep 27;31(1):29-43. doi: 10.1038/emboj.2011.357. https://www.ncbi.nlm.nih.gov/pubmed/21952048

Wyatt L, Wadham C, Crocker LA, Lardelli M, Khew-Goodall Y. The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial mesenchymal transition, and organ development. J Cell Biol. 2007 Sep 24;178(7):1223-35. http://jcb.rupress.org/content/178/7/1223

Ocaña OH, Córcoles R, Fabra Á, Moreno-Bueno G, Acloque H, Vega S, Barrallo-Gimeno A, Cano A, Nieto MA. Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1. Cancer Cell. 2012;[Epub ahead of print] doi:10.1016/j.ccr.2012.10.012. http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00442-4?elq=8da151b1453e4b69b21e1390b738e067

Rogers CD, Saxena A, Bronner ME. Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT. J Cell Biol. 2013;[Epub ahead of print] doi:10.1083/jcb.201305050. http://jcb.rupress.org/content/early/2013/11/25/jcb.201305050.abstract

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Cell Migration and Cancer Metastasis

Xu H, Ye D, Behra M, Burgess S, Chen S, Lin F. G?1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Dev Biol. 2014 Jan 15;385(2):316-27. doi: 10.1016/j.ydbio.2013.10.027. Epub 2013 Nov 4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134875/

Ruprecht V, Wieser S, Callan-Jones A, Smutny M, Morita H, Sako K, Barone V, Ritsch-Marte M, Sixt M, Voituriez R, Heisenberg C-P. Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility. Cell. 2015;160(4):673-85. doi:10.1016/j.cell.2015.01.008. http://www.cell.com/cell/abstract/S0092-8674%2815%2900009-4

Giger FA, Dumortier JG, David NB. Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos. J Vis Exp. 2016;110):e53792. doi:10.3791/53792. https://www.jove.com/video/53792/analyzing-vivo-cell-migration-using-cel...

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Wnt/beta-Catenin Signaling in Cancer

Park DS, Seo JH, Hong M, Choi SC. Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling. Biochem Biophys Res Commun. 2013 Jun 3. doi:pii: S0006-291X(13)00911-X. 10.1016/j.bbrc.2013.05.104. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/labs/articles/23743195/

Ossipova O, Bardeesy N, DePinho RA, Green JB. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol. 2003 Oct;5(10):889-94. Epub 2003 Sep 14. https://www.ncbi.nlm.nih.gov/pubmed/12973359

Cruciat CM, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M, Niehrs C. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science. 2010 Jan 22;327(5964):459-63. https://www.ncbi.nlm.nih.gov/pubmed/20093472

Brott BK, Sokol SY. Frodo proteins: modulators of Wnt signaling in vertebrate development. Differentiation. 2005 Sep;73(7):323-9. https://www.ncbi.nlm.nih.gov/pubmed/16219036

Toru? A, Szyma?ska E, Castanon I, Woli?ska-Nizio? L, Bartosik A, Jastrz?bski K, Mi?tkowska M, González-Gaitán M, Miaczynska M. Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling. PLoS One. 2015 Jun 25;10(6):e0130818. doi: 10.1371/journal.pone.0130818. eCollection 2015. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130818

Lin KY, Kao SH, Lai CM, Chen CT, Wu CY, Hsu HJ, Wang WD. Tumor Suppressor Lzap Suppresses Wnt/?-catenin signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of GSK3. J Biol Chem. 2015 Oct 16. pii: jbc.M115.669309. [Epub ahead of print]. http://www.jbc.org/content/290/50/29808.abstract

Gillis WQ, Kirmizitas A, Iwasaki Y, Ki DH, Wyrick JM, Thomsen GH. Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin. Cell Commun Signal. 2016 Aug 2;14(1):15. doi: 10.1186/s12964-016-0138-x. http://biosignaling.biomedcentral.com/articles/10.1186/s12964-016-0138-x

Griffin JN, del Viso F, Duncan AR, Robson A, Kulkarni S, Liu KJ, Khokha MK. RAPGEF5 regulates nuclear translocation of beta-catenin. bioRXiv. 2017. doi:10.1101/152892. http://www.biorxiv.org/content/early/2017/06/20/152892

Nakamura Y, de Paiva Alves E, Veenstra GJ, Hoppler S. Tissue- and stage-specific Wnt target gene expression is controlled subsequent to beta-catenin recruitment to cis-regulatory modules. Development. 2016 Jun 1;143(11):1914-25. doi: 10.1242/dev.131664. Epub 2016 Apr 11. http://dev.biologists.org/content/143/11/1914

Kim W, Khan SK, Gvozdenovic-Jeremic J, Kim Y, Dahlman J, Kim H, Park O, Ishitani T, Jho EH, Gao B, Yang Y. Hippo signaling interactions with Wnt/beta-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2016 Nov 21. pii: 88486. doi: 10.1172/JCI88486. [Epub ahead of print]. https://www.jci.org/articles/view/88486

Kim M, Kim S, Lee SH, Kim W, Sohn MJ, Kim HS, Kim J, Jho EH. Merlin inhibits Wnt/beta-catenin signaling by blocking LRP6 phosphorylation. Cell Death Differ. 2016 Jun 10. doi: 10.1038/cdd.2016.54. [Epub ahead of print]. http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd201654a.html

Zhu X, Min Z, Tan R, Tao Q. NF2/Merlin is required for the axial pattern formation in the Xenopus laevis embryo. Mech Dev. 2015 Sep 3. pii: S0925-4773(15)30025-3. doi: 10.1016/j.mod.2015.08.008. [Epub ahead of print]. http://www.sciencedirect.com/science/article/pii/S0925477315300253

Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. The c-Cbl Ubiquitin Ligase Regulates Nuclear beta-Catenin and Angiogenesis by Its Tyrosine Phosphorylation Mediated through the Wnt Signaling Pathway. J Biol Chem. 2015;290:12537-46. doi:10.1074/jbc.M114.616623. http://www.jbc.org/content/290/20/12537.abstract

Jayakumar MK, Bansal A, Li BN, Zhang Y. Mesoporous silica-coated upconversion nanocrystals for near infrared light-triggered control of gene expression in zebrafish. Nanomedicine (Lond). 2015 Apr;10(7):1051-61. doi: 10.2217/nnm.14.198. http://www.futuremedicine.com/doi/abs/10.2217/nnm.14.198

Schwarz-Romond T, Asbrand C, Bakkers J, Kuhl M, Schaeffer HJ, Huelsken J, Behrens J, Hammerschmidt M, Birchmeier W. The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 2002 Aug 15;16(16):2073-84. https://www.ncbi.nlm.nih.gov/pubmed/12183362

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Ovarian Cancer:

Ptaszynska MM, Pendrak ML, Bandle RW, Stracke ML, Roberts DD. Positive Feedback between Vascular Endothelial Growth Factor-A and Autotaxin in Ovarian Cancer Cells. Mol Cancer Res. 2008 Mar;6(3):352-63. https://www.ncbi.nlm.nih.gov/pubmed/18337445

Eyre R, Harvey I, Stemke-Hale K, Lennard TW, Tyson-Capper A, Meeson AP. Reversing paclitaxel resistance in ovarian cancer cells via inhibition of the ABCB1 expressing side population. Tumour Biol. 2014 Jul 4. [Epub ahead of print]. http://link.springer.com/article/10.1007%2Fs13277-014-2277-2

Joshi HP, Subramanian IV, Schnettler EK, Ghosh G, Rupaimoole R, Evans C, Saluja M, Jing Y, Cristina I, Roy S, Zeng Y, Shah VH, Sood AK, Ramakrishnan S. Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. PNAS. 2014;111 (14):5331-5336. published ahead of print March 24, 2014. doi:10.1073/pnas.1317242111. http://www.pnas.org/content/early/2014/03/21/1317242111.short

Furlong F, Fitzpatrick P, O'Toole S, Phelan S, McGrogan B, Maguire A, O'Grady A, Gallagher M, Prencipe M, McGoldrick A, McGettigan P, Brennan D, Sheils O, Martin C, W Kay E, O'Leary J, McCann A. Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer. J Pathol. 2012 Apr;226(5):746-55. doi: 10.1002/path.3035. Epub 2012 Jan 17. https://www.ncbi.nlm.nih.gov/pubmed/22069160

Schenk PW, Boersma AW, Brandsma JA, den Dulk H, Burger H, Stoter G, Brouwer J, Nooter K.. SKY1 is involved in cisplatin-induced cell kill in Saccharomyces cerevisiae, and inactivation of its human homologue, SRPK1, induces cisplatin resistance in a human ovarian carcinoma cell line.. Cancer Res. 2001 Oct 1;61(19):6982-6. http://cancerres.aacrjournals.org/content/61/19/6982

Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W.. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.. J Exp Med. 2006 Apr 17;203(4):871-81. Epub 2006 Apr 10.. https://www.ncbi.nlm.nih.gov/pubmed/16606666

Villegas-Pineda JC, Toledo-Leyva A, Osorio-Trujillo JC, Hernández-Ramírez VI, Talamás-Rohana P. The translational blocking of ?5 and ?6 integrin subunits affects migration and invasion, and increases sensitivity to carboplatin of SKOV-3 ovarian cancer cell line. Exp Cell Res. 2017 Jan 25. pii: S0014-4827(17)30019-8. doi: 10.1016/j.yexcr.2017.01.010. [Epub ahead of print]. http://www.sciencedirect.com/science/article/pii/S0014482717300198 Pancreatic Cancer:

Weiss FU, Marques IJ, Woltering JM, Vlecken DH, Aghdassi A, Partecke LI, Heidecke CD, Lerch MM, Bagowski CP. Retinoic acid receptor (RAR) antagonists inhibit miR-10a expression and block metastatic behaviour of pancreatic cancer. Gastroenterology. 2009 Sep 9. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/19747919

Zhou W, Liang IC, Yee NS. Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer. Cancer Biol Ther. 2011 Apr 1;11(7):659-70. Epub 2011 Apr 1. https://www.ncbi.nlm.nih.gov/pubmed/21301206

Yee NS, Zhou W, Liang IC. Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Dis Model Mech. 2011 Mar;4(2):240-54. Epub 2010 Dec 23. https://www.ncbi.nlm.nih.gov/pubmed/21183474

Kaneko K, Satoh K, Masamune A, Satoh A, Shimosegawa T. Expression of ROCK-1 in Human Pancreatic Cancer: Its Down-Regulation by Morpholino Oligo Antisense Can Reduce the Migration of Pancreatic Cancer Cells In Vitro. Pancreas. 2002 Apr;24(3):251-7. https://www.ncbi.nlm.nih.gov/pubmed/11893932

Ding X-Z, Iversen P, Cluck MW, Knezetic JA, Adrian TE. Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. Biochem Biophys Res Commun 1999 Jul 22;261(1):218-23. http://www.sciencedirect.com/science/article/pii/S0006291X99910124

Kobayashi H, Spilde TL, Bhatia AM, Buckingham RB, Hembree MJ, Prasadan K, Preuett BL, Imamura M, Gittes GK. Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions. Gastroenterology. 2002 Oct;123(4):1331-40. https://www.ncbi.nlm.nih.gov/pubmed/12360493

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Pancreatic and Gastric

Azoitei N, Pusapati GV, Kleger A, Möller P, Küfer R, Genze F, Wagner M, van Lint J, Carmeliet P, Adler G, Seufferlein T. Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours. Gut. 2010 Aug 23. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/20732914

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Prostate Cancer:

Boysen G, Barbieri CE, Prandi D, Blattner M, Chae SS, Dahija A, Nataraj S, Huang D, Marotz C, Xu L, Huang J, Lecca P, Chhangawala S, Liu D, Zhou P, Sboner A, de Bono JS, Demichelis F, Houvras Y, Rubin MA. SPOP mutation leads to genomic instability in prostate cancer. Elife. 2015 Sep 16;4. pii: e09207. doi: 10.7554/eLife.09207. https://elifesciences.org/articles/09207

Zhu ZH, Yu YP, Zheng ZL, Song Y, Xiang GS, Nelson J, Michalopoulos G, Luo JH. Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death. Am J Pathol. 2010 Sep;177(3):1176-86. Epub 2010 Jul 22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928952/

Zammarchi F, Boutsalis G, Cartegni L. 5? UTR Control of Native ERG and of Tmprss2:ERG Variants Activity in Prostate Cancer. PLoS ONE. 2013;8(3):e49721. doi:10.1371/journal.pone.0049721. https://www.ncbi.nlm.nih.gov/pubmed/23472063

Truman JP, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A. Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem. 2005 Jun 17;280(24):23262-72. Epub 2005 Apr 18. http://www.jbc.org/content/280/24/23262.full.html

Luo KL, Luo JH, Yu YP. (-)-Epigallocatechin-3-gallate induces Du145 prostate cancer cell death via downregulation of inhibitor of DNA binding 2, a dominant negative helix-loop-helix protein. Cancer Sci. 2009. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/20002680

London CA, Sekhon HS, Arora V, Stein DA, Iversen PL, Devi GR. A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. Cancer Gene Ther. 2003 Nov;10(11):823-32. https://www.ncbi.nlm.nih.gov/pubmed/14605668

Ko YJ, Devi GR, London CA, Kayas A, Reddy MT, Iversen PL, Bubley GJ, Balk SP. ANDROGEN RECEPTOR DOWN-REGULATION IN PROSTATE CANCER WITH PHOSPHORODIAMIDATE MORPHOLINO ANTISENSE OLIGOMERS. J Urol. 2004 Sep;172(3):1140-1144. https://www.ncbi.nlm.nih.gov/pubmed/15311058

Iversen PL, Arora V, Acker AJ, Mason DH, Devi GR. Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. Clin Cancer Res. 2003 Jul;9(7):2510-9. https://www.ncbi.nlm.nih.gov/pubmed/12855625

Faintuch BL, Núñez GE, Teodoro R, Moro AM, Mengatti J. Radiolabeled nano-peptides show specificity for an animal model of human PC3 prostate cancer cells. Clinics (Sao Paulo). 2011;66(2):327-36. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059864/

Devi GR. Prostate cancer: status of current treatments and emerging antisense-based therapies. Curr Opin Mol Ther. 2002 Apr;4(2):138-48. Review. https://www.ncbi.nlm.nih.gov/pubmed/12044035

Devi GR. XIAP as target for therapeutic apoptosis in prostate cancer. Drug News Perspect. 2004 Mar;17(2):127-34. https://www.ncbi.nlm.nih.gov/pubmed/15098067 Devi GR, Oldenkamp JR, London CA, Iversen PL. Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells. Prostate. 2002 Nov 1;53(3):200-10. https://www.ncbi.nlm.nih.gov/pubmed/12386920

Amantana A, London CA, Iversen PL, Devi GR. X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells. Mol Cancer Ther. 2004 Jun;3(6):699-707. https://www.ncbi.nlm.nih.gov/pubmed/15210856

Bezzerides VJ, Zhang A, Xiao L, Simonson B, Khedkar SA, Baba S, Ottaviano F, Lynch S, Hessler K, Rigby AC, Milan D, Das S, Rosenzweig A. Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Sci Rep. 2017;7:346. doi:10.1038/s41598-017-00413-3. http://www.nature.com/articles/s41598-017-00413-3

Lahvic JL, Ammerman MB, Li P, Yang S, Chiang N, Chase M, Weis O, Zhou Y, Serhan C, Zon LI. Eicosanoid-GPCR Signaling Enhances Hematopoiesis and Marrow Transplant. Blood. 2016;128(22):495. http://www.bloodjournal.org/content/128/22/495

Fukushima T, Yoshihara H, Furuta H, Kamei H, Hakuno F, Luan J, Duan C, Saeki Y, Tanaka K, Iemura S-I, Natsume T, Chida K, Nakatsu Y, Kamata H, Asano T, Takahashi S-I. Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. Nat Comm. 2015;6:6750. doi:10.1038/ncomms7780. http://www.nature.com/ncomms/2015/150416/ncomms7780/full/ncomms7780.html...

Wan X, Ji W, Mei X, Zhou J, Liu JX, Fang C, Xiao W. Negative Feedback Regulation of Wnt4 Signaling by EAF1 and EAF2/U19. PLoS One. 2010 Feb 9;5(2):e9118. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009118

Vetterkind S, Morgan KG. The Pro-Apoptotic Protein Par-4 Facilitates Vascular Contractility by Cytoskeletal Targeting of Zipk. J Cell Mol Med. 2008 May 24. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700217/

Lu J, Xin S, Meng H, Veldman M, Schoenfeld D, Che C, Yan R, Zhong H, Li S, Lin S. A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay. PLoS ONE. 2013;8(4):e53317. doi:10.1371/journal.pone.0053317. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053317

Lecosnier S, Cordier C, Simon P, François JC, Saison-Behmoaras TE. A steric blocker of translation elongation inhibits IGF-1R expression and cell transformation. FASEB J. 2011 Mar 14. [Epub ahead of print]. http://www.fasebj.org/content/25/7/2201.abstract

Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell. 2008 Jan 11;132(1):113-24. https://www.ncbi.nlm.nih.gov/pubmed/18191225

Hoeppner LH, Phoenix KN, Clark KJ, Bhattacharya R, Gong X, Sciuto TE, Vohra P, Suresh S, Bhattacharya S, Dvorak AM, Ekker SC, Dvorak HF, Claffey KP, Mukhopadhyay D. Revealing the role of phospholipase C?3 in the regulation of VEGF-induced vascular permeability. Blood. 2012;[Epub ahead of print] doi: 10.1182/blood-2012-03-417824. https://www.ncbi.nlm.nih.gov/pubmed/22674805

Haririan M, Kaviani S, Soleimani M, Ghaemi SR, Delalat B, Atashi A. Morpholino Oligo Antisense efficiently suppresses BCR/ABL and cell proliferation in CML: specific inhibition of BCR-ABL gene expression by Morpholino Oligo Antisense in BCR-ABL(+) cells. Hematology. 2012 Jan;17(1):28-34. https://www.ncbi.nlm.nih.gov/pubmed/22549445

Ellett F, Kile BT, Lieschke GJ. The role of the ETS factor erg in zebrafish vasculogenesis. Mech Dev. 2008 Nov 8. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/19027849

Catena R, Muniz-Medina V, Moralejo B, Javierre B, Best CJ, Emmert-Buck MR, Green JE, Baker CC, Calvo A. Increased expression of VEGF(121)/VEGF(165-189) ratio results in a significant enhancement of human prostate tumor angiogenesis. Int J Cancer. 2007 May 15;120(10):2096-109.. https://www.ncbi.nlm.nih.gov/pubmed/17278099

Buysse K, Riemersma M, Powell G, van Reeuwijk J, Chitayat D, Roscioli T, Kamsteeg E-J, van den Elzen C, van Beusekom E, Blaser S, Babul-Hirji R, Halliday W, Wright GJ, Stemple DL, Lin Y-Y, Lefeber DJ, van Bokhoven H. Missense mutations in ?-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker-Warburg syndrome. Hum Mol Genet. 2013;[Epub ahead of print] doi:10.1093/hmg/ddt021 . https://www.ncbi.nlm.nih.gov/pubmed/23359570

Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, Jernigan DL, Dean JL, Fatatis A, McDonnell DP, Visakorpi T, Feng FY, Knudsen KE. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. J Clin Invest. 2013 Jan 2;123(1):493-508. doi: 10.1172/JCI64750. Epub 2012 Dec 21. https://www.ncbi.nlm.nih.gov/pubmed/23257359

Pluskota E, Dowling JJ, Gordon N, Golden JA, Szpak D, West XZ, Nestor C, Ma YQ, Bialkowska K, Byzova T, Plow EF. The integrin co-activator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish. Blood. 2011 May 5;117(18):4978-87. Epub 2011 Mar 4.. https://www.ncbi.nlm.nih.gov/pubmed/21378273

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Skin Cancer:

Antonio N, Bønnelykke?Behrndtz ML, Ward LC, Collin J, Christensen IJ, Steiniche T, Schmidt H, Feng Y, Martin P. The wound inflammatory response exacerbates growth of pre?neoplastic cells and progression to cancer. EMBO J. 2015;[Epub ahead of print] doi:10.15252/embj.201490147. http://emboj.embopress.org/content/early/2015/06/30/embj.201490147

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie1 JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, David H. Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young YA, Zon LI. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molec Cell. 2016:62(1)34-46. doi:10.1016/j.molcel.2016.03.013. http://www.sciencedirect.com/science/article/pii/S1097276516002239

Ploper D, Taelman VF, Robert L, Perez BS, Titz B, Chen HW, Graeber TG, von Euw E, Ribas A, De Robertis EM. MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E420-9. doi: 10.1073/pnas.1424576112. Epub 2015 Jan 20. http://www.pnas.org/content/112/5/E420.long

Ploper D, Taelman VF, Robert L, Perez BS, Titz B, Chen HW, Graeber TG, von Euw E, Ribas A, De Robertis EM. MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells. Proc Natl Acad Sci U S A. 2015 Jan 20. pii: 201424576. [Epub ahead of print]. http://www.pnas.org/content/112/5/E420.full

Heck DE, Vetrano AM, Mariano TM, Laskin JD. UVB light stimulates production of reactive oxygen species: unexpected role for catalase. J Biol Chem. 2003 Jun 20;278(25):22432-6. https://www.ncbi.nlm.nih.gov/pubmed/12730222

Greenhill ER, Rocco A, Vibert L, Nikaido M, Kelsh RN. An Iterative Genetic and Dynamical Modelling Approach Identifies Novel Features of the Gene Regulatory Network Underlying Melanocyte Development. PLoS Genet. 2011;7(9): e1002265. doi:10.1371/journal.pgen.1002265. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10...

Guo L, Liew HP, Camus S, Goh AM, Chee LL, Lunny DP, Lane EB, Lane DP. Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish. Oncogene. 2012 Oct 15. doi: 10.1038/onc.2012.409. [Epub ahead of print].

Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, Eisenberg-Lerner A, Shohat G, Zhang M, Laudet V, Kimchi A, Bernet A, Mehlen P. The Dependence Receptor UNC5H2/B Triggers Apoptosis via PP2A-Mediated Dephosphorylation of DAP Kinas. Mol Cell. 2010 Dec 22;40(6):863-76. https://www.ncbi.nlm.nih.gov/pubmed/21172653

Göoz P, Göoz M, Baldys A, Hoffman S. ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis. Biochem Biophys Res Commun. 2009 Feb 27;380(1):33-8. Epub 2009 Jan 14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875258/

Heck DE, Vetrano AM, Mariano TM, Laskin JD. UVB light stimulates production of reactive oxygen species: unexpected role for catalase. J Biol Chem. 2003 Jun 20;278(25):22432-6. https://www.ncbi.nlm.nih.gov/pubmed/12730222

Greenhill ER, Rocco A, Vibert L, Nikaido M, Kelsh RN. An Iterative Genetic and Dynamical Modelling Approach Identifies Novel Features of the Gene Regulatory Network Underlying Melanocyte Development. PLoS Genet. 2011;7(9): e1002265. doi:10.1371/journal.pgen.1002265. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10...

Guo L, Liew HP, Camus S, Goh AM, Chee LL, Lunny DP, Lane EB, Lane DP. Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish. Oncogene. 2012 Oct 15. doi: 10.1038/onc.2012.409. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/23069659

Bailey CM, Morrison JA, Kulesa PM. Melanoma revives an embryonic migration program to promote plasticity and invasion. Pigment Cell & Melanoma Research. 2012;[Epub ahead of print] doi:10.1111/j.1755-148X.2012.01025.x. https://www.ncbi.nlm.nih.gov/pubmed/22681858

Liu CJ, Xie L, Cui C, Chu M, De Zhao H, Yao L, Li YH, Schachner M, Shen YQ. Beneficial roles of melanoma cell adhesion molecule in spinal cord transection recovery in adult zebrafish. J Neurochem. 2016 Jun 18. doi: 10.1111/jnc.13707. [Epub ahead of print]. http://onlinelibrary.wiley.com/doi/10.1111/jnc.13707/abstract

Strizzi L, Postovit LM, Margaryan NV, Lipavsky A, Gadiot J, Blank C, Seftor RE, Seftor EA, Hendrix MJ. Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention. Expert Rev Dermatol. 2009;4(1):67-78. https://www.ncbi.nlm.nih.gov/pubmed/19885369

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Testicular Cancer:

Neumann JC, Chandler GL, Damoulis VA, Fustino NJ, Lillard K, Looijenga L, Margraf L, Rakheja D, Amatruda JF. Mutation in the type IB bone morphogenetic protein receptor alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proc Natl Acad Sci U S A. 2011 Jul 20. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/21775673

Basten SG, Davis EE, Gillis AJM, van Rooijen E, Stoop H, Babala N, Logister I, Heath ZG, Jonges TN, Katsanis N, Voest EE, van Eeden FJ, Medema RH, Ketting RF, Schulte-Merker S, Looijenga LHJ, Giles RH. Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas. PLoS Genet. 2013;9(4):e1003384. doi:10.1371/journal.pgen.1003384. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.10...

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Thyroid Cancer:

Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCF(?-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med. 2012 Jul 2;209(7):1289-307. doi: 10.1084/jem.20112446. Epub 2012 Jun 18. http://jem.rupress.org/content/209/7/1289